MDR Bacterial Infections Our Treatment Option

Definition & Action of KPC, CRKP and CRECRE = carbapenem-resistant or carbapenemase-producingEnterobacteriaceaeCRKP = carbapenem-resistant Klebsiella pneumoniaeKPC = Klebsiella pneumoniae carbapenemaseThe organism can "Pop From one Strain to Another“The organism produces an enzyme that• degrades a very powerful antibiotic• confers low-level carbapenem resistance• is on a transferable genetic element• can pop from one strain to another and potentially fromone species to another and [be transmitted] from personto person and patient to patientKPCs display substantial carbapenem hydrolysis & is only weakly inhibited by clavulanic acid & tazobactamKPCs alone reduce susceptibility to carbapenems, they do not confer resistanceTo achieve full resistance to carbapenems, impaired outer-membrane permeability is often required