MDR Bacterial Infections Our Treatment Option

Early Combination Rx vs. Monotherapyin Septic ShockThe beneficial impact of combination therapy applied to• Gram-positive infection• Gram-negative infection• BUT was restricted to patients treated with• Beta-lactams in combination with (either one)1. Aminoglycosides2. Fluoroquinolones3. Macrolides/clindamycinKumar A, Zarychanski R, Light B, Parrillo J, Maki D, Simon D, Laporta D, et al. Early combination antibiotic therapy yields improvedsurvival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med 2010;38:1773-85.