MDR Bacterial Infections Our Treatment Option

Therapeutic Efficacy of Vancomycin in Relationto MIC or Bactericidal ActivityVancomycin Therapy in MRSA BacteremiaSuccess rate % Success rate %10010080604056%20 n = 910%0n =21≤ 0.5 1.0-2.0Vancomycin (MIC, ug/ml)P value < 0.0580P value < 0.056050%40200Exposure of MRSA 10 7 to 10 8 CFU/ml tovancomycin (16 µg/ml) for 72 hr.n = 90%23%n = 13n = 86.26Log 10 of Killing (CFU/ml)Sakoulas G, Moise-Broder PA, Schentag J, Forrest A, Moellering RC Jr, Eliopoulos GM. Relationship of MIC and bactericidal activity toefficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremia J Clin Microbiol 2004;42:2398-402.