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Page 18 | Bulletin 93 | September 2015<br />

www.niaa-hsrc.org.uk<br />

■■<br />

Patients under the care of an<br />

anaesthetist undergoing general,<br />

regional or local anaesthesia and/or<br />

sedation.<br />

■■<br />

Reactions occurring between<br />

administration of the first drug by<br />

the anaesthetist up to the time of<br />

discharge from the recovery room.<br />

■■<br />

Allergic and non-allergic<br />

(anaphylactoid) reactions.<br />

■■<br />

All ages.<br />

■■<br />

England, Northern Ireland, Scotland<br />

and Wales.<br />

There are four components to NAP6:<br />

1. Baseline Survey for<br />

Anaesthetists:<br />

5 November 2015<br />

In this survey we will ask all<br />

anaesthetists to provide a limited<br />

amount of specific information about<br />

their experience with perioperative<br />

anaphylaxis during the previous 12<br />

months. Data will be anonymised.<br />

2. Baseline Survey for Allergy<br />

Clinics:<br />

5 November 2015<br />

Allergy clinics in the UK will be asked<br />

to provide information about the<br />

services they provide to patients with<br />

suspected perioperative anaphylaxis.<br />

3. Main data collection:<br />

5 November 2015 for 1 year<br />

Detailed, anonymised information<br />

will be collected about every case of<br />

suspected Grade 3-5 perioperative<br />

anaphylaxis in the UK, including<br />

presentation, initial management,<br />

investigation and long-term adverse<br />

sequelae.<br />

4. Activity (allergen) Survey:<br />

April 2016<br />

As with the NAP5 activity survey, every<br />

anaesthetist will be asked to collect<br />

data for each patient they anaesthetise<br />

during a specified two-day period. The<br />

survey will not duplicate data collected<br />

in NAP5 but will collect numerical<br />

information about perioperative<br />

exposure to potential allergens,<br />

including certain anaesthetic drugs,<br />

antibiotics, IV colloids etc. This survey<br />

will act as a denominator to inform<br />

conclusions regarding the relative risks<br />

of anaphylaxis.<br />

The important role of Local<br />

Coordinators<br />

The format of NAP6 will be similar to<br />

previous NAPs: in every UK hospital,<br />

anaesthetists will report their cases to<br />

a Local Coordinator (LC), a consultant<br />

colleague who has volunteered for this<br />

role. The RCoA is extremely grateful<br />

to LCs, without whom these important<br />

national audit projects would be<br />

impossible. LCs will be responsible for<br />

coordinating the reponses to the baseline<br />

survey and the activity survey, as well as<br />

publicising NAP6 within their hospital.<br />

Every UK anaesthetic department will<br />

be asked to nominate a consultant<br />

anaesthetist for this role. This could<br />

be someone who has fulfilled this role<br />

during a previous NAP, or a consultant<br />

who has a particular interest in<br />

perioperative anaphylaxis, for example.<br />

What will happen to the data?<br />

Only anonymized data will be collected<br />

at all stages of the project. Data will be<br />

held on a secure server with passwordprotected<br />

access with the appropriate<br />

regulatory approvals. The NAP6 team<br />

extracting the data and the NAP6<br />

reviewing panel will be unaware of the<br />

identity of the patient, the hospital<br />

and the anaesthetist(s). The reviewing<br />

panel will include anaesthetists,<br />

allergists, immunologists and patient<br />

representatives. Each case reported<br />

during the main data-collection period<br />

will be discussed by the reviewing panel<br />

with reference to the presenting clinical<br />

features, suspected trigger agent,<br />

management, referral for subsequent<br />

investigation, eventual diagnosis, and<br />

the advice given by the allergy clinic to<br />

the patient and the anaesthetist. Where<br />

published guidelines exist, comparisons<br />

will be drawn, but the main purpose of<br />

NAP6 is descriptive.<br />

Publishing the results<br />

A comprehensive report will be<br />

published in early 2018. The results of<br />

the baseline surveys may be published at<br />

an earlier date. The report will include<br />

detailed analysis of the pattern of UK<br />

perioperative anaphylaxis, as well as<br />

pointing to potential improvements in<br />

avoidance, diagnosis and management.<br />

Please look out for further<br />

information relating to NAP6, and<br />

be prepared for the start of this<br />

exciting project on 5 November.<br />

We would be delighted to receive<br />

your comments and answer any<br />

questions you may have about the<br />

project.

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