AAHS ASPN ASRM - 2013 Annual Meeting - American Association ...

10:19am - 10:21am
Discussion
10:21am - 10:23am
Treatment of Painful Neuroma by End-to-End Neurorraphy and a Nerve
Conduit
Institution where the work was prepared: Georgetown University Hospital,
Washington, DC, USA
Ivica Ducic, MD, PhD; Ali Al-Attar, MD
10:23am - 10:24am
Discussion
10:24am - 10:28am
Ballistic Injuries of Peripheral Nerves: Clinical Aspects
Institution where the work was prepared: Tel Aviv Sourasky Medical Center, Tel
Aviv, Israel
Shimon Rochkind, MD; Tzvi Shlitner, MD; Malvina Alon, MD; Nachum
Chudnovsky, MD; Moshe Graif, MD
10:28am - 10:30am
Discussion
Moderators: Jonathan M. Winograd, MD
Tessa Gordon, PhD
10:30am - 10:35am
*The Cystic Transverse Limb of the Articular Branch: A Pathognomonic Sign
for Peroneal Intraneural Ganglion Cysts at the Superior Tibiofibular Joint
Institution where the work was prepared: Mayo Clinic, Rochester, MN, USA
Nicholas M. Desy, BSc; Kimberly K.amrami, MD; Robert J. Spinner, MD
10:35am - 10:37am
Discussion
10:37am - 10:41am
*Functional Effects of Locally Applied Thyroid Hormones in Sciatic Nerve
Regeneration in Rats
Institution where the work was prepared: National University of Athens, Athens,
Greece
Ioannis Papakostas, Dr; Iordanis Mourouzis; Kostas Mourouzis; Constantinos
Pantos; Nikolaos Gerostathopoulos; Dimitrios Ntallas, Dr; George Macheras, Dr;
Efstathios Boviatsis, Dr
10:41am - 10:43am
Discussion
10:43am - 10:47am
Peripheral Nerve Injury in the Axolotl: a Model of Embryonic Regeneration
Institution where the work was prepared: New York University School of Medicine,
New York, NY, USA
Stephen M. Russell, MD; Kartik Krishnan; Mark Schweitzer; Zehava Rosenberg;
Moses Chao
10:47am - 10:49am
Discussion
10:49am - 10:53am
Sensory Protection Modulates Neurotrophic Factor Expression in Distal Nerve
Stump Following Denervation
Institution where the work was prepared: McMaster University, Hamilton, ON,
Canada
Margaret Fahnestock, PhD; Bernadeta Michalski; James Bain, MD, MSc
10:53am - 10:55am
Discussion
10:55am - 10:59am
The Source and Pattern of Motor Collateral Sprouting and Nerve Regeneration
in End-to-Side Nerve Repair of Nerve to Medial Gastrocnemius in the Rat
Institution where the work was prepared: Bernard O’Brien Institute of
Microsurgery, Melbourne, Australia
Alan Hussey, FRCS(Plast); Richard Brower; Aurora Messina; Wayne Morrison
68
10:59am - 11:01am
Discussion
11:01am - 11:05am
*A New and Novel Model of Peripheral Nervous System Response to
Experimental Immunological Demyelination
Institution where the work was prepared: University of California, Irvine, Orange,
CA, USA
Aaron M. Kosins, BS; Michael P. McConnell, MD; Charles Mendoza; Brandon
Shepard; Sanjay Dhar, PhD; Gregory RD Evans, MD, FACS; Hans S. Keirstead, PhD
11:05am - 11:07am
Discussion
11:07am - 11:13am
*Demystifying Histomorphometry: A Serial Approach to Nerve Morphometry
Institution where the work was prepared: Washington University School of
Medicine, St. Louis, MO, USA
Arash Moradzadeh, MD; Elizabeth L. Whitlock, BA; Susan E. Mackinnon, MD;
Daniel A. Hunter, RA
11:13am - 11:15am
Discussion
11:15am - 11:19am
*Induction of Regional Collateral Sprouting Following Muscle Denervation
Institution where the work was prepared: Washington University School of
Medicine, St. Louis, MO, USA
Arash Moradzadeh, MD; JW Koob, BA; Alice Tong; Ayato Hayashi, MD; Terence
M. Myckatyn, MD; Thomas H. Tung, MD; Susan E. Mackinnon, MD
11:19am - 11:21am
Discussion
11:30am – 1:00pm Lunch Break (Lunch not provided)
1:00pm – 2:00pm Invited Speaker: Tessa Gordon, PhD
Sponsored by:
Tessa Gordon, PhD. Center for Neuroscience, Division of
Physical Therapy and Rehabilitation, Faculty of Medicine,
University of Alberta, Edmonton, Alberta
Emerging Strategies to Improve Outcome
of Nerve Injury
Despite the capacity for injured peripheral nerves to
regenerate their axons, functional outcome may be poor,
especially for injuries that require axon regeneration over
considerable distances. We established that the long
durations that neurons remain chronically axotomized prior
to target reinnervation and the chronic denervation
of the Schwann cells in the distal nerve stumps, severely
curtail the success of axon regeneration, and in turn, functional
recovery. I will review our data demonstrating the
effectiveness of exogenous neurotrophic factors in sustaining
the regenerative capacity of chronically axotomized
motoneurons and a strategy of using cytokines to
reactivate Schwann cells, to promote their proliferation, and
thereby to promote regeneration of axons through
chronically denervated distal nerve stumps. A key and to
date largely unrecognized site of considerable delay is the
surgical suture site. I will describe experiments in which we
demonstrate that a very long period of 4 weeks is required
for all neurons to regenerate their axons across the surgical
junction between proximal and distal nerve stumps in rats,
the reported latent period of days corresponding only to a
small proportion of the axons that cross the lesion site
within the time period. We found that low frequency
stimulation of the proximal nerve stump for just 1hour after
surgery accelerates the axon outgrowth across the lesion site
in association with up-regulation of neurotrophic factors in
the motor and sensory neurons. I will communicate our
recent translation of these exciting findings to human
patients who suffered moderate to severe carpal tunnel
syndrome prior to surgery. We found that the same 1 hour
period of electrical stimulation proximal to the site of carpal
tunnel release surgery promoted axon regeneration such
that the number of reinnervated motor units in the thenar
muscles of the patient group of stimulation increased to
normal levels within 6-8 months as compared to a trend for
unstimulated median nerves to regenerate but
for the motor unit numbers not to approach normal levels
within 1 year of surgery. This significant increase found in