AAHS ASPN ASRM - 2013 Annual Meeting - American Association ...

the numbers of reinnervated motor units with electrical
stimulation was accompanied by increased manual
dexterity (Purdue Pegboard test), reduced symptom
severity (Levine symptom severity questionnaire), and
improved skin sensation (Semmes-Weinstein monofilaments).
These data indicate that electrical stimulation at
the time of surgical repair is a feasible strategy to promote
axonal regeneration in humans and that it has the
potential to improve functional outcomes after surgical
repair of injured peripheral nerves. This strategy opens
opportunities to enhance axon regeneration after
peripheral nerve injury by combining with brief electrical
stimulation to promote axon out-growth across the
suture site with strategies to sustain both the regenerative
capacity of the axotomized neurons and Schwann cell
support of the regenerating axons over distance and time.
(I wish to thank the CIHR of Canada for their financial
support of this work).
2:00pm - 4:00pm SCIENTIFIC PAPER
PRESENTATIONS SESSION C
*Designates resident/fellow paper presentations
Moderators: Paul S. Cederna, MD
Maria Siemionow, MD, PhD
2:00pm - 2:04pm
A Novel Method of Head Fixation for the Study of Rodent Facial Function
Institution where the work was prepared: Massachusetts Eye and Ear Infirmary,
Boston, MA, USA
Tessa A. Hadlock, MD; Susan Mackinnon; James T. Heaton, PhD
2:04pm - 2:06pm
Discussion
2:06pm - 2:10pm
Small Fibers Dysfunction during Entrapment Neuropathy and after Surgical
Decompression in a Rat Model
Institution where the work was prepared: Ching-Hua Hsieh, Kaohsiung, Taiwan
Ching-Hua Hsieh, MD; Tsu-Hsiang Lu, BA; Seng -Feng Jeng, MD; Shun-Sheng
Chen, MD, PhD
2:10pm - 2:12pm
Discussion
2:12pm - 2:16pm
Harvested Human Neurons Engineered as Live Nervous Tissue Constructs:
Implications for Transplantation
Institution where the work was prepared: University of Pennsylvania, Philadelphia,
PA, USA
Eric L. Zager, MD; Jason H. Huang, MD; Jun Zhang, MD; Robert G. Groff, BA;
Bryan J. Pfister, PhD; Eileen Maloney-Wilensky, CRNP; Akiva S. Cohen, PhD; M.
Sean Grady, MD; Douglas H. Smith, MD
2:16pm - 2:18pm
Discussion
2:18pm - 2:24pm
*In Vivo Bioluminescence Imaging of Schwann cells in a Nerve Conduit
Institution where the work was prepared: Department of Plastic Surgery,
Groningen, Netherlands
M.S. Ma; J.C.V.M. Copray; G.M. van Dam; H.W.G.M. Boddeke; M.F. Meek, MD, PhD
2:24pm - 2:26pm
Discussion
2:26pm - 2:30pm
*Nerve Fiber and Motor Neuron Count Variation with Time After Nerve Injury
Institution where the work was prepared: Washington University, Saint Louis, MO,
USA
Ida K. Fox, MD; Daniel A. Hunter; Susan E. Mackinnon
2:30pm - 2:32pm
Discussion
69
2:32pm - 2:38pm
*Use of Skin-Derived Stem Cells to Promote Peripheral Nerve Regeneration and
Recovery from Chronic Denervation
Institution where the work was prepared: University of Calgary, Hotchkiss Brain
Institute, Calgary, AB, Canada
Sarah K. Walsh, BSc; J. Biernaskie; F. Miller; Raj Midha, MD, MSc
2:38pm - 2:40pm
Discussion
2:40pm - 2:44pm
Collagen Nerve Protectors in Rat Sciatic Nerve Repair: A Functional and
Mechanical Analysis
Institution where the work was prepared: Columbia University Medical Center,
Department of Ortho. Surgery, New York, NY, USA
Austin G. Hayes, BS; Charles M. Jobin, MD; Yelena Akelina, DVM; Melvin P.
Rosenwasser, MD
2:44pm - 2:46pm
Discussion
2:46pm - 2:50pm
In Vivo Enhancement of Spinal Axon Outgrowth by Sialidase in a Rat Model of
Brachial Plexus Avulsion
Institution where the work was prepared: Johns Hopkins School of Medicine,
Baltimore, MI, USA
Lynda js Yang, MD, PhD; Ronald Schnaar, PhD
2:50pm - 2:52pm
Discussion
2:52pm - 2:56pm
*Effects of Motor Versus Sensory Nerve Architecture on Regeneration Through
Cold Preserved Nerve Grafts
Institution where the work was prepared: Washington University School of
Medicine, St. Louis, MO, USA
Arash Moradzadeh, MD; Christopher M. Nichols, MD; Jason W. Koob, BA; Daniel
A. Hunter, RA; Susan E. Mackinnon, MD
2:56pm - 2:58pm
Discussion
2:58pm - 3:02pm
Live image analysis of Schwann cell-axonal relationship in peripheral nerve
allografts
Institution where the work was prepared: Washington University in St. Louis
School of Medicine, St. Louis, MO, USA
Ayato Hayashi; Terence M. Myckatyn, MD; Alice Y. Tong, MS; Daniel A. Hunter,
RA; Daniel Z. Liu, BA; Jason W. Koob, BA; Arash Moradzadeh, MD; Jamie D.
Gaertner; Thomas H. Tung, MD; Susan E. Mackinnon, MD
3:02pm - 3:04pm
Discussion
Moderators: A. Lee Dellon, MD
Thomas Tung, MD
3:04pm - 3:10pm
*Multiple Costimulatory Pathway Inhibition for Nerve Allograft Regeneration
Institution where the work was prepared: Washington University in St. Louis
School of Medicine, St. Louis, MO, USA
Chau Y. Tai, MD; Jaime Gaertner; Dan A Hunter; Thomas H Tung
3:10pm - 3:12pm
Discussion
3:12pm - 3:16pm
*A Dose Dependent Facilitation and Inhibition of Early Peripheral Nerve
Regeneration by Nerve Growth Factor (NGF) Through a Novel T-tube Chamber:
Effects on the Establishment of an In Vivo Concentration Gradient
Institution where the work was prepared: University of Calgary and the Hotchkiss
Brain Institute, Calgary, AB, Canada
Stephen W.P. Kemp, BSc(Hons), MSc; Sarah K. Walsh, BSc; Douglas Zochodne; Raj
Midha, MD, MSc