VACCINE

Immunology And Allergy Clinics Of North America • November 2003
Aluminum inclusion macrophagic myofasciitis:
a recently identified condition
Author information
Gherardi RK1, Authier FJ.
Muscle and Nerve Group
Henri Mondor University Hospital
Créteil, France
lauret@univ-paris12.fr
Abstract
The authors conclude that the persistence of aluminum hydroxide at the site of intramuscular
injection is a novel finding which has an exact significance that remains
to be established fully. It seems mandatory to evaluate possible long-term adverse
effects induced by this compound, because this issue has not been addressed (in the
past, aluminum hydroxide was believed to be cleared quickly from the body). If
safety concerns about the long-term effects of aluminum hydroxide are confirmed,
novel and alternative vaccine adjuvants to rescue vaccine-based strategies should
be proposed to ensure the enormous benefit for public health that these vaccines
provide worldwide.
“The authors conclude
that the persistence of aluminum hydroxide
at the site of intramuscular injection is a novel
finding which has an exact significance
that remains to be established fully.”
http://www.ncbi.nlm.nih.gov/pubmed/?term=14753387