VACCINE

Transplant Infectious Disease • November 2015
High rate of vaccine failure after administration of acellular pertussis vaccine
pre- and post-liver transplantation in children at a children’s hospital in Japan
Author information
Ito K1,2, Kasahara M3, Saitoh A1,4, Honda H5, Miyairi I1.
1. Division of Pediatric Infectious Diseases, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan
2. Department of Infectious Diseases, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
3. Division of Transplant Surgery, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
4. Department of Pediatrics, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan
5. Division of Infectious Diseases, Tokyo Metropolitan Tama General Medical Center, Tokyo, Japan
Abstract
“A high rate of pertussis vaccine failure
was observed, 44.8% against the pertussis toxin
and 69.0% against filamentous hemagglutinin ...”
We assessed the serological response to pertussis vaccines administered pre- and post-liver transplantation in 58 pediatric patients
at a children’s hospital in Japan. A high rate of pertussis vaccine failure was observed, 44.8% against the pertussis toxin
and 69.0% against filamentous hemagglutinin, with no difference in the seropositivity rate with respect to the timing of the vaccination
during the peritransplant period.
http://www.ncbi.nlm.nih.gov/pubmed/26565897