VACCINE

Journal Of Toxicology And Environmental Health Part B Critical Reviews • 2007
Human Health Risk Assessment For
Aluminum, Aluminum Oxide, And Aluminum Hydroxide
Author Information
Daniel Krewski,1,2 Robert A Yokel,3 Evert Nieboer,4
David Borchelt,5 Joshua Cohen,6 Jean Harry,7 Sam Kacew,2,8 Joan Lindsay,9
Amal M Mahfouz,10 and Virginie Rondeau11
1. Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
2. McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Ontario, Canada
3. College of Pharmacy and Graduate Center for Toxicology, University of Kentucky Medical Center, Kentucky, USA
4. Department of Biochemistry and Biomedical Sciences, McMaster University
Hamilton, Ontario, Canada and Institute of Community Medicine, University of Tromsø, Norway
5. SantaFe Health Alzheimer’s Disease Research Center, Department of Neuroscience, McKnight Brain Institute, University of Florida, USA
6. Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, USA
7. National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
8. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
9. Aging-Related Diseases Section, Surveillance Division, Public Health Agency of Canada, Ottawa, Ontario, Canada
10. United States Environmental Protection Agency, Washington DC, USA
11. INSERM E0338 (Biostatistic), Université Victor Segalen Bordeaux 2, Bordeaux, France
Corresponding Author: Daniel Krewski
Professor and Director, McLaughlin Centre for Population Health Risk Assessment
University of Ottawa, Room 320, One Stewart Street, Ottawa, Ontario
Tel: 613-562-5381, Fax: 613-562-5380
Findings
“This report classified the weight of evidence for each exposure pathway and health effect as strong, modest,
limited, or having no clear evidence (see Table 25). We concluded that there is strong evidence that aluminum
can cause irritation following exposure via either inhalation or injection. Modest evidence of an effect
exists for reproductive toxicity following oral exposure, for neurological toxicity following either oral or
injection exposure, and for bone toxicity following injection exposure.”
“Modest evidence
of an effect exists for
reproductive toxicity following oral exposure,
for neurological toxicity following either oral or
injection exposure, and for bone toxicity
following injection exposure.”
Full Report
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782734/