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Infectious Disease Clinics Of North America • December 2011<br />

The common immunogenic etiology<br />

of chronic fatigue syndrome:<br />

from infections to vaccines via adjuvants<br />

to the ASIA syndrome<br />

Author information<br />

Rosenblum H1, Shoenfeld Y, Amital H.<br />

Department of Medicine B<br />

Sheba Medical Center<br />

Sackler Faculty of Medicine<br />

Tel Aviv University, Ramat Aviv<br />

Tel-Hashomer 52621, Israel<br />

Abstract<br />

Chronic fatigue syndrome (CFS) is characterized by unexplained fatigue<br />

that lasts for at least 6 months with a constellation of other symptoms. Most<br />

cases start suddenly, and are usually accompanied by a flu-like illness. It<br />

is a symptom-based diagnosis of exclusion, the pathogenesis of which is<br />

unknown. Studies have examined and hypothesized about the possible biomedical<br />

and epidemiologic characteristics of the disease, including genetic<br />

predisposition, infections, endocrine abnormalities, and immune dysfunction<br />

and psychological and psychosocial factors. Recently, the AISA (autoimmune/inflammatory<br />

syndrome induced by adjuvants) syndrome was<br />

recognized, indicating the possible contribution of adjuvants and vaccines<br />

to the development of autoimmunity.<br />

“Recently, the AISA<br />

(autoimmune/inflammatory syndrome induced by adjuvants)<br />

syndrome was recognized, indicating the possible contribution<br />

of adjuvants and vaccines to the development of autoimmunity.”<br />

http://www.ncbi.nlm.nih.gov/pubmed/22054760

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