VACCINE

Vaccine • 1993
Studies on the toxicities
of aluminium hydroxide and calcium phosphate
as immunological adjuvants for vaccines
Author information
Goto N1, Kato H,
Maeyama J, Eto K, Yoshihara S.
Department of Safety Research on Biologics
National Institute of Health, Tokyo, Japan
Abstract
Aluminium hydroxide (Al) and calcium phosphate (Ca) have been used for
many years as immunological adjuvants for biologicals. We investigated
the toxic effects of both adjuvants with different physical properties. Al-gel
elicited vascular permeability-increasing and toxic effects to macrophages
(M phi), while its haemolytic effect was weak. Ca-gel elicited a significantly
stronger haemolytic effect, but no other toxic effect. Incubation of
M phi or polymorphonuclear leucocytes with Al-suspension resulted in the
largest release of lactate dehydrogenase. Ca-suspension caused haemolysis
of about 50% of that caused by Ca-gel.
“Aluminum-gel elicited vascular
permeability-increasing and toxic
effects to macrophages ...”
http://www.ncbi.nlm.nih.gov/pubmed/8212836