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Tennessee Nurse - May 2021

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Page 20 <strong>Tennessee</strong> <strong>Nurse</strong> <strong>May</strong>, June, July <strong>2021</strong><br />

COVID-19 Vaccinations:<br />

Knowledge vs. Myth to Get Back to A New Normal<br />

Erin Morgan, DNP, FNP-BC<br />

In <strong>Tennessee</strong>, the COVID-19 virus has infected 826,371<br />

people, and 12,022 individuals have lost their lives as of<br />

April 13, <strong>2021</strong>. The virus has become the third leading<br />

cause of death in the United States for 2020. Now<br />

that multiple vaccinations are more widely available,<br />

nurses can educate the public about their options and<br />

dispel the myths surrounding these important tools<br />

to decrease future COVID-19 infections and deaths.<br />

<strong>Nurse</strong>s have remained the most trusted profession<br />

throughout the pandemic, and therefore, must use this<br />

position to inform the public about their vaccine options.<br />

Understandably, individuals may remain hesitant to Erin Morgan<br />

obtain a new vaccine when they still have unanswered<br />

questions. <strong>Nurse</strong>s have always provided detailed education to allow individuals<br />

to make the most informed choice for their health. Information surrounding<br />

COVID-19 vaccination is no different.<br />

Vaccine Options<br />

Currently, there are three COVID-19 vaccines approved for emergency use<br />

authorization (EUA) in the United States, two-dose Pfizer or Moderna Vaccines<br />

and the single-dose Johnson and Johnson-Janseen vaccine. <strong>Nurse</strong>s should<br />

recommend individuals receive any vaccine that is available to them. The<br />

FDA has deemed all of the vaccines safe and effective to prevent infection<br />

and severe complications from COVID-19. This recommendation applies to all<br />

individuals, not just those who have co-morbidities. As more individuals are<br />

vaccinated against the virus, the number of available individuals COVID-19 can<br />

reside continues to decrease.<br />

mRNA Vaccines<br />

The Pfizer vaccine was first approved for use in December 2020, with the<br />

Moderna vaccine approval following shortly after. Both vaccines require two<br />

doses; 21 days between Pfizer doses and 28 days between Moderna doses.<br />

These two vaccines use messenger RNA to provide COVID-19 immunity. This<br />

mRNA technology has been studied for years and has already been used in<br />

some cancer treatments. These vaccines use mRNA to instruct cells to make<br />

a ‘spike protein’ similar to that of the COVID-19 virus. The recipient’s immune<br />

system responds to these new proteins by making antibodies. These new<br />

antibodies remain with the recipient to recognize the similar ‘spike protein’ if a<br />

COVID-19 infection occurs. The mRNA does not change the vaccine recipient’s<br />

DNA; instead, it trains the immune system how to respond if the virus is<br />

encountered.<br />

Side effects for the Pfizer and Moderna vaccines include pain or swelling at<br />

the vaccine site, fever, muscle aches, fatigue, or headache. These symptoms<br />

may occur after the first or second dose. Individuals who have had COVID-19<br />

may have more side effects with the first dose. However, many individuals who<br />

have not had COVID-19 report more side effects after a second dose.<br />

Viral Vector Vaccine<br />

The Johnson and Johnson-Janssen vaccine is the most recent to receive<br />

approval. This vaccine is a single-dose injection that offers convenience and<br />

expediency compared to the other two vaccine options. This vaccine was<br />

tested later during the pandemic resulting in differing effectiveness data that<br />

should not be compared to the Pfizer or Moderna vaccines. Additionally, the<br />

Johnson and Johnson-Janssen vaccine was tested in locations where variants<br />

of COVID-19 were already circulating, affecting results of the study. The use<br />

of this vaccine was paused to examine six blood clotting events in women.<br />

Nevertheless, the Johnson and Johnson-Janssen vaccine has already been<br />

received by millions of individuals to date.<br />

The Johnson and Johnson-Janssen vaccine provides immunity through a<br />

viral vector instead of mRNA. Viral Vectors, non-infectious harmless viruses,<br />

are used to transmit information to the recipient’s immune system. The vector<br />

instructs the recipients’ immune system how to produce antibodies for the<br />

‘spike protein’ recognizable on the COVID-19 virus. While considered effective<br />

after two weeks per the CDC, immunity increases up to 28 days past the single<br />

dose. Viral vector vaccines have already been used to treat cancer and the<br />

Ebola virus.<br />

Side effects are similar to the previous two vaccines and include pain or<br />

swelling at the vaccine site, fever, muscle aches, fatigue, or headache. The CDC<br />

recommends that women between the ages of 18-50 who receive the Johnson<br />

and Johnson-Janssen vaccine should be aware of the rare but increased risk of<br />

thrombocytopenia syndrome. Any individual who feels uncomfortable with this<br />

risk is recommended to obtain one of the other two vaccine options.<br />

Vaccine Hesitancy<br />

Many patients and fellow nurses have questions and concerns about<br />

these new vaccinations. These apprehensions are valid and may take time to<br />

overcome. One way to dispel myths and answer questions surrounding these<br />

vaccines is to provide evidence-based education from trusted sources and then<br />

let the patient or nurse choose for themselves.<br />

The process was rushed<br />

All medications and vaccines must go through an approval process with the<br />

FDA. All three vaccinations currently approved have undergone this process<br />

and received emergency use authorization (EUA). This approval does not mean<br />

that the steps for approval were shortened or skipped; instead, it provides<br />

approval for widespread use in the pandemic when benefit is demonstrated.<br />

Scientists were able to accelerate the development of these vaccines<br />

due to several factors. Scientists shared information between countries and<br />

between companies in an unprecedented effort to roll out multiple COVID-19<br />

vaccine options at once. Cooperation occurred in the scientific community<br />

using methods that were already in progress, such as viral vector and mRNA<br />

technology, developed for a new purpose. Moreover, governments provided<br />

funding to help cover costs for the development of vaccines locally and abroad;<br />

in the United States, this was titled “Operation Warp Speed.” Additionally,<br />

many volunteers of varying ages and races enrolled in the vaccine trials<br />

decreasing the time to find participants. Finally, vaccine developers were able<br />

to move through the phases of vaccine development promptly. Phase 3 trials<br />

were completed relatively quickly due to the infectious and widespread nature<br />

of COVID-19, when many participants were exposed, proving effectiveness. All<br />

of these factors allowed multiple vaccines to be developed in a time of great<br />

need.

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