Abstracts (poster) - Wissenschaft Online
Abstracts (poster) - Wissenschaft Online
Abstracts (poster) - Wissenschaft Online
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Osman El-Maarri 1 , Tim Becker 2 , Thomas Mikeska 3 , Judith Junen 1 , Syed Saadi<br />
Manzoor 1 , Amalia Diaz-Lacava 2 , Rainer Schwaab 1 , Thomas Wienker 2 , Andreas Waha 3 ,<br />
Johannes Oldenburg 1<br />
Association analysis between DNA methylation from total<br />
blood and polymorphisms in DNA methyltransferase (DNMT)<br />
genes in healthy individuals: A tendency toward higher<br />
methylation levels in males<br />
To examine the contribution of polymorphisms in DNMT genes to methylation variations<br />
we performed a search for polymorphisms in coding regions of all known human DNA<br />
methyltransferases genes (DNMT1, 3A, 3B, 3L and 2=TRDMT1) in 96 normal males and<br />
96 normal females. Global methylation was estimated by studying two repetitive DNA<br />
elements, namely Line-1 and Alu repeats, while single loci were investigated at three<br />
differentially methylated regions: PEG3, NESP55 and H19; two additional single loci were<br />
also studied at Xq28 and 19q13.4. All studied CpGs showed a slightly higher methylation<br />
in males (P
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