Profilaksa DVT kod velikih ortopedskih operacija - Depol ...

20 - 22 September 2012, Opatija, Croatia
USE OF BIODEGRADABLE MATERIALS AND STEM CELLS IN THE
TREATMENT OF BONE DEFECTS
Gamze Torun Kose, Yeditepe University, Faculty of Engineering and Architecture, Department of Genetics
and Bioengineering, Istanbul, Turkey, BIOMATEN, METU Center of Excellence in Biomaterials and Tissue
Engineering, Ankara, Turkey
There are a large number of people suffering from an organ or tissue loss due to injury, infection, or disease. Currently,
major approaches to solve this problem are surgical reconstruction, transplantation or use of prosthesis.
Although these therapies have saved and improved countless lives, they remain imperfect solutions due to occurrence
of infection, chronic irritation, donor shortages, tissue rejection, and longer term complications such as
development of malignant tumor.
Tissue engineering, the development of cell seeded 3D biomaterials for introduction to the defect area is the current
solution for all of the problems mentioned above.
Cell Guidance is a branch of tissue engineering that offers controlled tissue regeneration and allows the repair
of the tissue by mimicking its natural organization to achieve better and faster integration with the native tissue.
Guidance is important especially for constructs for nerve and bone tissues because of their significant levels of
organization and anisotropy.
In one of the study conducted by our research group BIOMATEN on bone tissue engineering, the aim was to
achieve improved attachment and uniform distribution of rat mesenchymal stem cell-derived osteoblasts by introducing
chemical and topographical cues on biopolyester film surfaces. Various patterns such as microgrooves
and micropits were introduced on the film surface by employing micropatterned silicon wafers. Results proved
that microtopographies could improve osseointegration especially when combined with chemical cues, and that
microgrooves and cell adhesive protein lines guided osteoblast adhesion on selective regions and improved alignment.
Oral
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