Profilaksa DVT kod velikih ortopedskih operacija - Depol ...

20 - 22 September 2012, Opatija, Croatia
CELL-BASED AND CELL-FREE JOINT IMPLANTS FOR CARTILAGE
REPAIR
Michaela Endres, TransTissue Technologies GmbH Berlin/ Germany
For 12 years now, BioTissue has been the pioneer in the field of regenerative cartilage treatment. BioTissue combines
the state of the art in bioengineering industry with the growing demands of the orthopedic market and
the future-oriented visions of science. This is achieved by a high-tech GMP lab, an independent R&D center, and of
course by eager clinical interaction with the physicians.
Articular cartilage cannot regenerate itself. Once damaged, the result is pain and loss of function. Treatment is
absolutely essential to prevent deterioration in conditions such as joint disease. Tissue engineering research had
led to the development of cell-based transplants for bone (BioSeed ® -oral bone) and cartilage repair (BioSeed ® -C).
BioSeed ® -C is an autologous 3-dimensional chondrocyte graft which has been successfully used for many years
to treat articular cartilage defects in the knee, ankle or hip. Therefore, a biopsy of cartilage tissue is taken from
the patient and cells are isolated and expanded. After 3 weeks, these cells are re-transplanted within a no woven
polymer matrix into the cartilage defect by mini-open or arthroscopic procedure. The autologous cell graft replaces
the missing tissue and restores the original function. It provides the chondrocytes (cartilage cells) with an
ideal three-dimensional but stable environment which stimulates them to redifferentiate and thus assume their
original morphology and function.
In contrast to cell-based cartilage repair, chondrotissue ® is a 1-step, CE marked, cell-free implant used to treat articular
cartilage defects in the knee, ankle or hip. It is used after bone-marrow stimulating techniques to repair focal
chondral defects by the possibility of an arthroscopic application. Within the defect it covers the microfractured
area, protects the subchondral bone and insures a stable 3D environment and a chondrogenic cell differentiation
into hyaline-like repair tissue formation. chondrotissue ® provides a unique stable 3D technology ensuring excellent
cell differentiation and allowing for stable fixation. By an easy and fast operation technique and arthroscopic
implantation possibility, cartilage defects can be treated using the cell-free one-step procedure with excellent
clinical outcome.
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