Profilaksa DVT kod velikih ortopedskih operacija - Depol ...

20 - 22 September 2012, Opatija, Croatia
DOUBLE BUNDLE TECHNIQUE COMBINED WITH A BIOLOGIC
REGENERATIVE TREATMENT GIVE THE BEST RESULT OF ACL
SURGERY
Nikica Daraboš, University Clinic for Traumatology, Clinical Hospital Center Sisters of Mercy, Zagreb, Croatia
Miroslav Hašpl, Special Hospital Acromion, Krapinske Toplice, Croatia
Denis Tršek, Special Hospital Acromion, Krapinske Toplice, Croatia
Carsten Moser, Institute for Microtherapy, University Witten-Herdecke, Bochum, Germany
The bone tunnel widening appear after knee anterior cruciate ligament (ACL) single bundle technique (SB) reconstruction
and could result in a ligament laxity or lead to increased failure rates. It could be affected on the
biomechanical and biomolecular base. This research was carried out to establish whether a double bundle technique
(DB) in a combination with.biologic regenerative treatment of intra-articular application of Autologous Conditioned
Serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth
factors, could enhance a result of ACL surgery.
In a prospective, randomized, double-blind trial with four parallel groups, 124 patients were treated. We compared
a tibial bone tunnel width measured by CT-scans in three different post-operative periods. The clinical efficacy was
assessed by patient administered outcome instruments (IKDC 2000, LYSHOLM, TEGNER) up to two years following
the ACL-reconstruction in 4 groups of patients regarding a different combination of treatment: A. SB + Placebo, B.
SB + ACS, C. DB + Placebo, D. DB + ACS.
Postoperative tibial tunnel diameters in all groups were significantly larger than they were directly after surgery.
Bone tunnel enlargement was significantly less in Group D than in the other groups (p