Profilaksa DVT kod velikih ortopedskih operacija - Depol ...

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82 2 st INTERNATIONAL CONFERENCE ON REGENERATIVE ORTHOPAEDICS ARTHROPLASTY BY DEMINERALIZED OSTEOCHONDRAL ALLOGRAFTS AS AN ALTERNATIVE TO EARLY TOTAL HIP ARTHROPLASTY IN CHILDREN WITH THE SEQUELAE OF OSTEOMYELITIS Yury Garkavenko, The Turner Scientific and Research Institute for Children’s Orthopedics, Saint-Petersburg – Pushkin, Russian Federation Alexandr Pozdeev, The Turner Scientific and Research Institute for Children’s Orthopedics, Saint-Petersburg – Pushkin, Russian Federation In the period from one to 26 years, the results were studied of the hip arthroplasty by demineralized osteochondral allografts in 52 patients with sequelae of osteomyelitis of the hip operated at the The Turner Research Institute for Children’s Orthopedics. The initial state of the affected hip with destructive hip dislocation was in 56 per cent of patients, in one third of patients was an ankylosis of the joint in a vicious position, and in 13% of patients was severe flexion-adduction contracture on the background of coxarthrosis, requiring joint stabilization and restoration of function. If indicated, the hip arthroplasty with the use of one or two demineralized osteochondral allografts was supplemented by shortening osteotomy of the femur in its lower third. The study has shown that in more than a half of the patients, namely in 27 (52%), flexion in the operated hip exceeded 80°, reaching 100° or more in 7 (13.5%) patients. In the late followup, in all 16 patients with initial ankylosis of the hip the range of motion in at least two planes has preserved. However, only in four patients (25%) of them the flexion did not exceed 45°, while in the remaining cases (75%) it exceeded 60°, reaching 100° or more in 9 (56.2%) patients. Despite the increase in number of patients during later followup with limited range of motion in the operated hip, the preservation of a sufficient range of flexion beyond 80º was observed in patients even 10-15 years (33.3%), and even 16-20 years (66, 6%) after performed arthroplasty. The results presented here provide a basis to consider the arthroplasty with the use of demineralized osteochondral allografts as an alternative to the early total hip arthroplasty in children with destructive changes in the proximal femur. Poster
20 - 22 September 2012, Opatija, Croatia HIP AND KNEE OSTEOARTHRITIS SUSCEPTIBILITY AND ASSOCIATION WITH IL1 GENE CLUSTER IN CROATIAN POPULATION Zdravko Jotanovic, Clinic for Orthopaedic Surgery Lovran, School of Medicine, University of Rijeka, Croatia Marikken Heiland Kaarvatn, Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway Godfrey Essien Etokebe, Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway Radovan Mihelic, Clinic for Orthopaedic Surgery Lovran, School of Medicine, University of Rijeka, Croatia Biserka Mulac-Jericevic, Department of Physiology and Immunology, School of Medicine, University of Rijeka, Croatia Tamara Tijanic, Department of Physiology and Immunology, School of Medicine, University of Rijeka, Croatia Sanja Balen, Clinical Institute for Transfusion Medicine, Universal Hospital Center Rijeka, School of Medicine, University of Rijeka, Croatia Branko Sestan, Clinic for Orthopaedic Surgery Lovran, School of Medicine, University of Rijeka, Croatia Zlatko Dembic, Molecular Genetics Laboratory, Department of Oral Biology, University of Oslo, Norway Osteoarthritis (OA) is a degenerative, chronic, progressive and multifactorial disease of the joints that causes degenerative changes in articular cartilage, but also causes pathological changes in other parts of the joint. It is the most common chronic musculoskeletal disease with complex genetic risk, and represents a leading cause of disability in elderly population worldwide. The risk for primary OA is polygenic in nature, with risk differing among various human subpopulations. One of the factors involved in the genetic predisposition to both hip OA (HOA) and knee OA (KOA) is the interleukin-1 (IL-1) gene cluster located on chromosome 2. Using case-control study in a Croatian Caucasian population with 500 OA patients, of which 240 KOA patients with total knee replacement (TKR) or partial knee replacement (PKR) and 260 HOA patients with total hip replacement (THR), and 508 healthy blood donors as controls, we have mapped genetic polymorphisms at 4 loci, comprising three SNPs: IL1A -889 (C>T), IL1B +3594 (C>T) and -511 (G>A), and a VNTR in the IL1RN gene. Further analyses were done by assembling haplotypes using our previous reports on markers for the same population (the IL1B -511C>T SNP and the IL1RN VNTR). Our results are consistent with a hypothesis that inflammatory factors like IL-1 are implicated in pathogenesis of primary OA. Poster 83
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FINAL PROGRAM BOOK OF ABSTRACTS ORG
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CONTENTS 20 - 22 September 2012, Op
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Organized by: Croatian Academy of S
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CONFERENCE PROGRAMME: September 21
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17:15 - 17:25 Discussion 20:00 Soci
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20 - 22 September 2012, Opatija, Cr
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BOOK OF ABSTRACTS 20 - 22 September
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STEM CELLS FOR THE CURIOUS Stanimir
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