Profilaksa DVT kod velikih ortopedskih operacija - Depol ...

20 - 22 September 2012, Opatija, Croatia
RISKS FACTORS FOR LOW BONE MINERAL DENSITY IN
POST-MENOPAUSAL WOMEN WITH SYSTEMIC SCLEROSIS
Anka Pranić-Kragić, Department of Nuclear Medicine, University Hospital Split, Split, Croatia
Mislav Radić, Department of Rheumatology and Clinical Immunology, University Hospital Split,
Split, Croatia
Dušanka Martinović Kaliterna, University Hospital Split, Split, Croatia
Josipa Radić, Department of Nephrology, University Hospital Split, Split, Croatia
The aim of this study was to determine the prevalence and risk factors for low bone mineral density (BMD) in
women with systemic sclerosis (SSc). A cross-sectional study was conducted among 32 post-menopausal SSc patients.
Patients were evaluated using a questionnaire about the following variables: age, disease duration, disease
activity, Medsger severity score, total skin score and history of fracture. Lumbar spine and hip measurements of
BMD were performed by dual absorptiometry. Univariate and multivariate statistical analyses were used to assess
the relationship between risk factors and BMD. The mean age was 52.8 +/- 10.7 years, and the median duration
of SSc was 78.8 +/- 65 months. The mean BMD was 1.29 +/- 0.18 g/cm(2) in the lumbar spine and 1.09 +/- 0.14 g/
cm(2) in the hip. Osteopenia was present in 26.4 % of patients and osteoporosis in 15.6 %. In the multiple regression
analysis, low BMD in the lumbar spine was associated with and low body mass index (BMI). Low BMD in the
hip was associated with cumulative corticosteroid dose Medsger severity score and low BMI. Medsger severity
score, low BMI, and total skin score are risks factors for low BMD in post-menopausal SSc patients. Osteopenia was
found in 26.4 % of patients, while osteoporosis was found in 15.6%. Bone health should receive attention in care
for persons with SSc.
Poster
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