HESBURGH LECTURE SERIES 2013 Program - Alumni Association ...

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Mayland Chang, Ph.D. Research Professor; Department of Chemistry and Biochemistry; Director, Notre Dame Project Development Team Biography Mayland Chang, research professor in the Department of Chemistry and Biochemistry, brings 22 years of experience in drug discovery and development, and clinical trials management. She has characterized the absorption, distribution, metabolism, and excretion (ADME) properties of numerous drug candidates in the areas of infectious, CNS, and metabolic Categories diseases, including delavirdine (a reverse transcriptase inhibitor, Rescriptor Tablets), atevirdine (a reverse transcriptase inhibitor), sonepiprazole (a D4-antagonist), linomide (an Notre Dame, Science anti-angiogenic), PNU-96391 (a D2-antagonist), and PNU-183792 (a non-nucleoside inhibitor of human cytomegalovirus). Chang also prepared the Rescriptor Tablets NDA and various IND applications, Investigator’s Brochures, product development plans, candidate drug evaluations, and acquisition of candidate drugs, as well as the ADME package for delavirdine in defense of the marketing approval with the U.S. FDA and the ADME section of delavirdine’s package insert. Before joining the University of Notre Dame, Chang was chief operating officer of University Research Network, Inc., where she established an academic research organization for Wayne State University School of Medicine that facilitated clinical research and provided clinical development services to the pharmaceutical and biotechnology industries. Previously, she was senior scientist with Pharmacia Corporation (Pfizer, Inc. as of 2003), and senior chemist at Dow Chemical Company. During her industrial career, Chang has seen three of her projects brought to commercialization (Rescriptor Tablets for the treatment of HIV, Broadstrike herbicide, and Tracer insecticide). More recently, she has studied the metabolism and pharmacokinetics of SB-3CT, a selective gelatinase inhibitor that shows efficacy in animal models of stroke and cancer metastasis. She has designed and evaluated watersoluble gelantinase inhibitors that show great promise in the treatment of neurological diseases. Chang holds bachelor’s degrees in biology and chemistry from the University of Southern Carolina, a Ph.D. in chemistry from the University of Chicago, and has completed a NIH postdoctoral fellowship at Columbia University. Her research interests center on defining and optimizing the ADME properties of pharmacologically active compounds and designing prodrugs with improved pharmaceutical and pharmacokinetic properties. Lecture Win Just One for the Gipper: Advances Toward Treatment of Traumatic Brain Injury Concussions are a prominent feature of sports, producing a cascade of neurological events, resulting in reduced blood flow to the brain, neuronal cell injury, and death. Presently, there is no treatment to rescue brain cells after each concussion. Notre Dame technology addresses this unmet medical need that has the potential for a first-in-kind treatment for TBI. 20 The Hesburgh Lecture Series, 2013 Program
Brian S. Collier, Ph.D. Graduate Faculty, Alliance for Catholic Education; Fellow, Institute for Educational Initiatives; Affiliate Faculty, Poverty Studies, American Studies, and Education, Schooling & Society Biography Brian Collier holds a Ph.D. in American Indian History and the History of Education in America from Arizona State University. He teaches for the Alliance for Catholic Education and is a fellow in the Institute for Educational Initiatives. His research in education is at the Categories intersection of where families and teachers can truly partner to take back their families, their schools, and their neighborhoods. His historical research on Native people focuses on Education, History, Social American Indian boarding schools and their legacy in the 20th century. Collier himself was Concerns a teacher at St. Catherine Indian School in Santa Fe before it closed its doors in 1998, and he learned a great deal about Native people and culture from that experience. Since that experience, he has studied the closure of Native American Catholic schools and Catholic education more broadly. Collier has written articles and book chapters on Native Americans, the American West, teaching in the American West, race relations, gender, and the Harlem Globetrotters. Lectures Creating an American Identity: American Indians and the Co-opting of Identity There are Apache helicopters, Jeep Cherokees, and Notre Dame sits next to Mishawaka, IN, said to be named for a Pottawatomie Princess. Even your breakfast butter likely has an “Indian” on it. There are numerous other examples of American places and brands that borrow from Native American life and culture. Does borrowing an indigenous identity somehow give Americans a better sense of belonging to this land and make them feel more at home on this continent? Is there any harm that comes from the Native images and stereotypes that we are surrounded by as a nation and culture? Our native narrative includes plenty of Native places and people, but what happens to a nation when myth and branding replace history and colonization? The lessons of co-opting an identity are harsh, but this is not a preachy lecture, but rather a thought provoking and humorous one designed to get people to question the choices they make and the identities they’ve created. Stories do have power in American history, and the stories we tell will be how we’re judged in the future. Save Our Schools, Save Our Country, and Save Your Family How did we get to the point where so many American schools struggle and yet so many kids are busier than any time since World War II. As families race to soccer practices and scouts, wait in drop-off lines and at oboe lessons, and sit through recitals, parents wonder how this is the fulfillment of the American dream. This lecture actually traces American education since the turn of the 20th century and shows what has changed and what some of our predecessors did really well to raise “the greatest generation.” What lessons can be learned from the schools who trained humans to go to the moon, write novels, plays, and create television programming? This engaging lecture also promises to be funny and cause everyone to go home with ideas about how to change their own family structure to ensure their kids are getting the education they need to help re-shape America. The Hesburgh Lecture Series, 2013 Program 21
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Friday, October 12 (Notre Dame vs.
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Notre Dame Alumni Association 100 E
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