HESBURGH LECTURE SERIES 2013 Program - Alumni Association ...
HESBURGH LECTURE SERIES 2013 Program - Alumni Association ...
HESBURGH LECTURE SERIES 2013 Program - Alumni Association ...
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Crislyn D’Souza-Schorey, Ph.D.<br />
Professor, Biology; Walther Cancer Institute Chair<br />
Biography<br />
Crislyn D’Souza-Schorey received her doctorate from the University of Texas Health Science<br />
Center at San Antonio, following which she was a postdoctoral research fellow and research<br />
assistant professor at Washington University School of Medicine in St. Louis. She joined the<br />
University of Notre Dame faculty as the Walther Cancer Institute Junior Chair in 1998. A major<br />
line of research investigation in her laboratory is to understand the molecular and cellular<br />
basis of initiation and progression of epithelial cancers. A second line of research involves<br />
understanding the molecular basis of rare neurodegenerative disorders such as Huntington’s<br />
disease.<br />
D’Souza-Schorey has received several awards and honors during her career, including the<br />
Robert Welch Pre-Doctoral Fellowship, the Lucille P. Markey Post Doctoral Fellowship in<br />
Pathobiology, the Leukemia Society of America Special Fellowship, Young Investigator Awards from the Leukemia Research<br />
Foundation, and the Michael K. Guest Award for Innovative Cancer Research. Research in her laboratory has been supported<br />
by federal and non-federal sources including the American Cancer Society, American Heart <strong>Association</strong>, U.S. Department of<br />
Defense, the National Institutes of Health, and the Walther Cancer Foundation (formerly, the Walther Cancer Institute).<br />
D’Souza-Schorey serves on scientific review panels of the National Institutes of Health and the U.S. Department of Defense-<br />
Breast Cancer Research <strong>Program</strong>. She also serves as a scientific reviewer for international funding agencies such as the<br />
Welcome Trust, the Dutch Cancer Society, and the Health Research Board of Ireland. At Notre Dame, she is actively involved in<br />
undergraduate and graduate education, both in the classroom and the laboratory.<br />
Lectures<br />
Fighting Cancer: Understanding Mechanisms of Cancer Progression<br />
The detachment of cancer cells from the surface of a tumor signals the beginning of a critical phase in the spread of some of the<br />
most notorious cancers, including cancers of the breast, prostate, ovary, and skin. This lecture will present newly discovered<br />
mechanisms that result in aggressive cancers that could serve as useful and effective platforms for diagnosis and therapeutics to<br />
complement existing strategies.<br />
Rare but Real: Understanding the Cellular Basis of Huntington’s Disease and Niemann-<br />
Pick Disease Type C<br />
A rare (or orphan) disease has a prevalence of fewer than 200,000 affected individuals in the United States. Huntington’s Disease<br />
(HD) and Niemann-Pick Disease Type C (NPC) are rare neurodegenerative disorders. While HD is predominately a late-onset<br />
disease that affects adults, NPC is most commonly a childhood disease. Both diseases are linked to genetic defects that result in<br />
misfolded proteins. This lecture will describe recent investigations on HD and/or NPC, which have identified new proteins of<br />
interest that are affected by, and perhaps regulators of, disease pathogenesis.<br />
34 The Hesburgh Lecture Series, <strong>2013</strong> <strong>Program</strong><br />
Categories<br />
Science