International Journal of Noni Research - Noni Family

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P. Rethinam et al. Noni (Morinda citrifolia L.) - the Miracle Fruit - a holistic review human in different health conditions. It was believed that the Noni fruit juice contained significant level of antioxidants. This has been proved scientifically by the analysis of TNJ. The study was designed to measure how the TNJ scavenged super oxide anion radicals (SAR) and quenched lipid peroxides (LPO) by TNB assay and LMB assay, respectively (Auerbach et al., 1992; Wang and Su, 2001). SAR scavenging activity was examined in vitro by Tettrazolium nitroblue (TNB) assay. The SAR scavenging activity of TNJ was compared to that of three known antioxidants; vitamins C, grape seed powder, and pyncogenol at the daily dose per serving level recommended by US RDA's or manufacturer's recommendations. Under the experimental conditions the SAR scavenging activity of TNJ was shown to be 2.8 times that of vitamin C, 1.4 times that of pyncogenol and 1.1 times that of grape seed powder. Therefore TNJ has a great potential to scavenge reactive oxygen free radicals (Wang and Su, 2001). Anti-inflammatory activity Evidences are indicating that COX-2 inhibitors may be involved in breast, colon, and lung cancer development (Yau et al., 2002; Takahashi et al., 2002; Langman et al., 2000). Research on anti-inflammatory has shown that the selectivity of COX- 2 inhibition of TNJ is comparable with that of Celebrex. The discovery of the selective COX-2 inhibition of TNJ is very significant since TNJ is a natural fruit juice without side effects this is the first scientific evidence for a strong antiinflammatory activity in TNJ, which may also be one of the mechanisms of cancer prevention (Zhang et al., 1994). The antiinflammatory activity was observed in an acute liver injury model in female SD rats induced by CCl4. A decrease in inflammatory foci and lymphocyte surrounding central vein areas were observed at 6 h post CCl4 administration in animals pre treated with 10% TNJ for twelve days in drinking water compared with CCl4 without TNJ (Wang et al., 2001). Research from this clinical trials indicated that cigarette-smoke is not only involved in cancer but also involved in pulmonary, heart and other degenerative diseases. However, drinking TNJ was beneficial for the prevention of heart, lung, and brain diseases as well as delaying the ageing processing, and maintaining overall good health. Wound healing activity It is well established that the Morinda leaf and fruit extracts are effective in healing the wounds. Surendiran (2004) studied the wound healing property of M. tinctoria using the animal model. The application of chloroform fruit extract of M. tinctoria topically on the excision wound surface of two different Intl. J. Noni Res. 2007, 2(1-2) 28
29 Intl. J. Noni Res. 2007, 2(1-2) doses accelerated the wound healing process by decreasing the surface area of the wound. The fruit extracts of M. tinctoria at 20 mg/ml significantly healed the wound in rats within 15 days where complete healing was observed against 60% in untreated control. On day 3, all the treated animals exhibited considerable increase in the percentage of wound contraction as compared to control. The wound contraction was significantly increased in the subsequent days due to treatment of fruit extract at 10 and 20 mg/ml as compared to control. Anti Lithiatic Effect Noni, Morinda citrifolia ,L has the anti Lithiatic effect on Ethylene Glycol induced Lithiasis in male albino rats.This observation provided the basis for considering Noni for inhibiting stone formation induced by ethylene glycol, (Murugesh and Christina2007). Anti fungal activity The observational study of the anti fungal activity of Morinda Citrifolia,L. fruit extract of Fusarium semitectrum had indicated the inhibitory activity for Morinda extract and it is equivalent to that of commercial available anti fungal agents,(Murugesh and Kannan, 2007). Epilogue P. Rethinam et al. Noni (Morinda citrifolia L.) - the Miracle Fruit - a holistic review The review presented here, is not a complete one, but by and large one could see that more to be done on germplasm assemblage, breeding, varietal / hybrid development, developing manurial and water management need to develop technologies for water / mixed / multiple cropping and integrated farming system. The prevalence of pest and disease and developing suitable bio management need to be given a fillip. Harvesting and post harvesting technique, reducing the post. Harvest lossess need attention. Being a new crop taken up for cultivation by farmers many technological gaps need to be filled up. References Abbott, I.A. 1985. The geographic origin of the plants most commonly used for medicine by Hawaiians. J. Ethnopharmacol. 14: 213-22. Abbott, I.A. 1992. La' Au Hawaii' traditional Hawaiian uses of plants V3. Honolulu, Hawaii: Bishop Museum Press. pp. 97-100.
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