Images - Department of Radiology & Biomedical Imaging ...

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radiology and biomedical imaging research
n Patients with:
• Epilepsy
• Traumatic brain injury
• NeuroENT (tinnitus, spasmodic dysphonia)
• Neuropsychiatric illnesses (schizophrenia, depression,
PTSD, lupus, Gulf War Syndrome)
• Multiple sclerosis, movement disorders (Parkinson’s disease,
focal hand dystonia), prion diseases (CJD)
• Neurodevelopmental disorders (autism, agenesis of the
corpus callosum, cerebral palsy)
• Neurodegenerative diseases (Alzheimer’s/MCI, FTD, ALS,
semantic dementia, PPA)
• Brain tumors
• Cerebrovascular disease (stroke, AVM, sickle cell disease)
Recent Key References:
Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M,
Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-
Tempini ML. White matter damage in primary progressive aphasias:
a diffusion tensor tractography study. Brain. 2011 Jun 11.
[Epub]
Hinkley LB, Vinogradov S, Guggisberg AG, Fisher M, Findlay AM,
Nagarajan SS. Clinical symptoms and alpha band resting-state
functional connectivity imaging in patients with schizophrenia:
implications for novel approaches to treatment. Biol Psychiatry.
2011 Aug 19. [Epub]
Li YO, Yang FG, Nguyen CT, Cooper SR, Lahue SC, Venugopal S,
Mukherjee P. Independent component analysis of DTI reveals
multivariate microstructural correlations of white matter in the
human brain. Hum Brain Mapp. 2011 May 12. [Epub]
Martino J, Honma SM, Findlay AM, Guggisberg AG, Owen JP,
Kirsch HE, Berger MS, Nagarajan SS. Resting functional connectivity
in patients with brain tumors in eloquent areas. Ann
Neurol. 2011 Mar;69(3):521-32. [Epub]
Raj A, Hess C, Mukherjee P. Spatial HARDI: improved visualization
of complex white matter architecture with Bayesian spatial
regularization. Neuroimage. 2011 Jan 1;54(1):396-409.
BREAST CANCER RESEARCH INTEREST GROUP
Nola Hylton, PhD, Co-Director
Bonnie N. Joe, MD, PhD, Co-Director
Research Directions:
The Breast RIG’s research aims are to advance imaging-based
approaches for breast cancer diagnosis, leading to earlier detec-
tion, reduction of disease recurrence, and improved survival. Our
major research areas include:
n MRI and spectroscopy to assess breast tumor response to
neoadjuvant chemotherapy. UCSF is the lead institution for
the national ACRIN 6657/I-SPY breast cancer clinical trial
testing MRI and molecular biomarkers for the prediction of
treatment response and survival for women receiving neo-
adjuvant chemotherapy for locally advanced breast cancer
n Computer-aided tools for real-time measurement of MRI biomarkers
for breast cancer
n MRI of ductal carcinoma in situ (DCIS) for staging and assessing
response to hormonal treatment
n Quantitative mammographic breast density measurement for
breast cancer risk assessment
n MRI-directed tissue biopsy for radiologic-pathologic correlation
of imaging and molecular biomarkers
n MRI measurement of breast density and tissue composition
Recent Key References:
Arasu VA, Chen RC, Newitt DN, Chang CB, Tso H, Hylton NM, Joe
BN. Can signal enhancement ratio (SER) reduce the number of
recommended biopsies without affecting cancer yield in occult
MRI-detected lesions? Acad Radiol. 2011 Jun;18(6):716-21.
McLaughlin R, Hylton N. MRI in breast cancer therapy monitoring.
NMR Biomed. 2011 Jul;24(6):712-20.
Partridge SC, Singer L, Sun R, Wilmes LJ, Klifa CS, Lehman CD,
Hylton NM. Diffusion-weighted MRI: influence of intravoxel
fat signal and breast density on breast tumor conspicuity and
apparent diffusion coefficient measurements. Magn Reson
Imaging. 2011 Sep 13. [Epub]
Peng C, Chang CB, Tso HH, Flowers CI, Hylton NM, Joe BN.
MRI appearance of tumor recurrence in myocutaneous flap
reconstruction after mastectomy. AJR Am J Roentgenol. 2011
Apr;196(4):W471-5.
Shepherd JA, Kerlikowske K, Ma L, Duewer F, Fan B, Wang
J, Malkov S, Vittinghoff E, Cummings SR. Volume of mammographic
density and risk of breast cancer. Cancer Epidemiol
Biomarkers Prev. 2011 Jul;20(7):1473-82.