Images - Department of Radiology & Biomedical Imaging ...

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radiology and biomedical imaging research
overall and cardiovascular mortality. The combination of these
elements, together with a program for educating and training
practitioners and scientists, will provide measurable benefits
to patients.
In summary, our mission is to:
n Use state-of-the-art imaging to understand the etiology of
multiple cardiovascular diseases
n Investigate the scientific basis for new imaging modalities
and their applications
n Apply cardiovascular imaging modalities to evaluate the
physiologic, pharmacologic, and molecular basis of disease
n Develop tools for early detection of cardiovascular diseases
n Assess the role of cardiac imaging to predict cardiovascular
outcomes to reduce overall and cardiac-related mortality.
Recent Key References:
Hope MD, Dyverfeldt P, Acevedo-Bolton G, Wrenn J, Foster E,
Tseng E, Saloner D. Post-stenotic dilation: Evaluation of ascending
aortic dilation with 4D flow MR imaging. Int J Cardiol. 2011
Sep 8. [Epub].
Muzzarelli S, Meadows AK, Ordovas KG, Hope MD, Higgins CB,
Nielsen JC, Geva T, Meadows JJ. Prediction of Hemodynamic
Severity of Coarctation by Magnetic Resonance Imaging. Am J
Cardiol. 2011 Aug 20. [Epub]
Ordovás, KG, Carlsson, M, Lease, KE, Foster, E, Meadows, AK,
Martin, AJ, Hope, M, Do, L, Higgins, CB, Saeed, M. Impaired
regional left ventricular strain after repair of tetralogy of fallot.
JMRI (in press).
Saeed M, Saloner D, Martin A, Wilson M. Cardiovascular magnetic
resonance imaging in delivering and evaluating the efficacy
of hepatocyte growth factor gene in chronic infarct scar
Cardiovasc Revasc Med. 2011 Mar-Apr;12(2):111-22.
Sayre GA, Bacharach SL, Dae MW, Seo Y. Combining dynamic
and ECG-gated 82Rb-PET for practical implementation in the
clinic. Nucl Med Commun. 2011 Sep 19. [Epub]
IMAGE-GUIDED THERAPY
SPECIALIZED RESOURCE GROUP
Alastair J. Martin, PhD, Co-Director
Steven W. Hetts, MD, Co-Director
Mark W. Wilson, MD, Co-Director
Research Directions:
The IGT SRG aims to be a world leader in developing new
and improved guidance for a wide array of surgical and inter-
ventional procedures. The administration of therapy is evolv-
ing and several common themes are emerging: (1) therapies
must be delivered in an efficacious manner; (2) therapies must
be administered in a minimally invasive fashion; (3) novel
therapies must achieve demonstrable benefits over existing
approaches; and (4) therapy delivery must be cost effective.
Imaging is central to all these goals and the IGT SRG aims to
bring together the clinical and technical expertise within our
department and in collaboration with external departments,
institutions, and industrial partners to develop delivery methods
that achieve optimized therapeutic results.
Our key objectives are to:
n Provide improved guidance and evaluation of therapy
n Perform interventions and therapy delivery in a more minimally
invasive fashion
n Develop image guidance for evolving medical therapies for
which there may not now exist acceptable delivery mechanisms
n Develop pre-clinical devices in collaboration with industrial
partners
n Conduct clinical trials that provide guidance to the medical
community as to best practices in the therapeutic management
of patients
Recent Key References:
Bernhardt AF, Wilson MW, Settecase F, Evans L, Malba V, Martin
AJ, Saeed M, Roberts TPL, Arenson RL, Hetts SW. Steerable