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550 - Farm Hosp. 2016;40(6):544-568 Ramón Morillo Verdugo et al.<br />

Table 1 (cont.). Bibliographic Review – Pharmaceutical Interventions in HIV+ Patients<br />

Title Authors, year<br />

Type of<br />

study<br />

No. Of<br />

participants<br />

Interventions Objective Time Conclusions<br />

Feasibility and<br />

reliability of<br />

interactive voice<br />

response assessment<br />

of HIV medication<br />

adherence: research<br />

and clinical<br />

implications.<br />

Hettema JE,<br />

Prospective<br />

et al. 2012 24<br />

63 patients<br />

Participants should<br />

communicate their daily<br />

adherence during 2 weeks<br />

in the voice system. The<br />

feasibility of the system<br />

was analyzed and,<br />

retrospectively, compared<br />

with the self-reported<br />

adherence data obtained<br />

during previous follow-up.<br />

A pilot study intended<br />

to assess the feasibility<br />

and reliability of an<br />

Interactive Voice<br />

Response System (IVR)<br />

for assessing treatment<br />

adherence.<br />

1 month<br />

The feasibility of these new<br />

promising systems should be<br />

improved. Besides, further<br />

studies should be conducted<br />

with another comparator<br />

for adherence measurement<br />

which is more adequate and<br />

representative.<br />

Development and<br />

validation of a<br />

predictive model for<br />

the identification<br />

of HIV-infected<br />

patients with Drug<br />

Related Problems: E.<br />

PREDICTOR<br />

Prospective,<br />

Morillo Verdugo<br />

multicenter,<br />

R, et al. 2012 25 open.<br />

733 patients<br />

Periodic<br />

pharmacotherapeutical<br />

follow-up in the PhC<br />

consultations at the<br />

Pharmacy Units in the<br />

hospitals included.<br />

To develop and validate<br />

a predictive model for<br />

detecting drug related<br />

problems (DRPs) in HIV<br />

patients on antiretroviral<br />

treatment.<br />

4 months<br />

The model developed<br />

and validated allows the<br />

detection of those patients<br />

on antiretroviral treatment<br />

at higher risk of developing<br />

a DRP.<br />

Impact of HIVspecialized<br />

pharmacies on<br />

adherence and<br />

persistence with<br />

antiretroviral therapy.<br />

Retrospective,<br />

comparative<br />

Murphy P, et al.<br />

study of<br />

2012 26 healthcare<br />

intervention<br />

7064 patients<br />

Review of medication,<br />

evaluation of adherence,<br />

ease in drug access and<br />

improvement in their<br />

availability.<br />

To assess and compare<br />

the adherence and<br />

persistence with ART by<br />

patients who use HIVspecialized<br />

pharmacies<br />

vs. traditional<br />

pharmacies.<br />

12<br />

months<br />

HIV-specialized community<br />

pharmacies can be effective<br />

means to help patients<br />

achieve a better adherence<br />

and persistence with ART.<br />

Pharmacists’<br />

strategies for<br />

promoting<br />

medication<br />

adherence among<br />

patients with HIV.<br />

Qualitative,<br />

Kibicho J, et al.<br />

multicenter,<br />

2011 27 descriptive.<br />

19<br />

Pharmacists<br />

Semi-structured interview to<br />

participants.<br />

To document the<br />

experience of<br />

pharmacists and provide<br />

a perspective about<br />

adherence barriers<br />

for HIV patients and<br />

describe the strategies<br />

to improve it.<br />

2 months<br />

Further research is required<br />

on the efficacy and costefficacy<br />

of interventions<br />

by Pharmacists in clinical<br />

practice, with the aim<br />

to reach a consensus on<br />

reimbursement policies.

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