Products at a Glance 2024

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www.pelobiotech.com • Low immunogenicity, reducing the risk of immune rejection when transplanted. Additionally, we offer a wide range of MSCs in research and GMP grade from various tissue sources, including canines, monkeys, dogs, mice, and humans, with different characteristics and applications, such as diseased models, conditionally immortalized cells, and those with GFP/RFP tags and cell RNA. For all of these MSCs we also offer corresponding media and tools. GMP MSCs We provide high-quality mesenchymal stromal cells (MSCs) for clinical and preclinical applications, offering both GMP and research-grade options. These cells are derived from 20 years of research and clinical experience at the Karolinska Institute, ensuring their quality. Our large-scale facility in Stockholm enables cost-effective production. • Adjustable quantity and vial size per dose. • Derived from bone marrow or adipose tissue of young, healthy volunteers. • Xeno-free and at Passage 3. • Offered with international delivery in liquid nitrogen. Exosomes These versatile cells cater to various research and clinical needs, with competitive pricing and delivery options for different requirements. Exosomes, small extracellular vesicles released by various cell types, have garnered significant attention for their diverse applications in both diagnostics and therapeutics. These tiny membrane-bound vesicles carry a cargo of proteins, nucleic acids, and lipids, facilitating intercellular communication. In diagnostics, exosomes serve as potential biomarkers for various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. Their non-invasive nature and specificity make them valuable in early disease detection. Moreover, exosomes hold promise in therapeutics, acting as natural delivery vehicles for drugs, RNA, or therapeutic proteins. Their ability to cross biological barriers, such as the blood-brain barrier, enhances their potential for targeted drug delivery. As research continues to unveil the intricate roles of exosomes, their applications are expanding, offering innovative solutions in personalized medicine and regenerative therapies. We offer exosomes produced from bone marrow mesenchymal stem cells which are CD9, CD63 and CD81 +ve, extensively tested and size and count verified by Zetaview. Also available are media (CellCor) and media supplements for exosome production using mesenchymal stem/stroma cells (see page 29-30). 12

www.pelobiotech.com Primary Cells In the realm of applied research, the selection of cell cultures is a critical determinant of the quality and relevance of scientific outcomes. Our commitment to maintaining the highest standards in cell quality has resulted in one of the most extensive portfolios of primary cells in Europe. To ensure the excellence of our cells, they undergo a rigorous process before they reach you. We also offer corresponding media for all the cells or custom media tailored to your requirements and all other possible cell culture tools. • Tissue Selection: Our meticulous tissue selection guarantees the highest quality primary cells, enhancing research reliability and are generally available at a cell density >0.5 million cells per vial check on our webpage for details. • Stringent Testing: We subject every isolation to comprehensive testing, including population doubling time, proliferation assays, and tests for specific markers, fungi, bacteria, mycoplasma, hepatitis B and C DNA, and HIV-1 DNA. • Donor Information: Certain cell types come with extensive donor data, enriching research with details like BMI, smoking history, gender, and medical history. • Species Diversity: Our extensive cell range spans mice, rats, hamsters, chickens, pigs, cats, dogs, cattle, and humans. Human cells can also be acquired from diseased or elderly donor sources, broadening research possibilities. • Quality Control: Automated liquid nitrogen control ensures consistent, high-quality cryopreserved cell batches, maintaining our stringent standards. Additional Services we provide: • Custom Cell Isolation: Researchers with specific requirements can take advantage of our custom cell isolation services. We offer the flexibility to work with general protocols or, if preferred, the researcher's own protocols, all at affordable prices. • Cell RNA: We offer cell RNA, providing a valuable resource for RNA sequencing work. • Tagged Cells: We provide cells tagged with markers such as GFP/RFP, facilitating tracking and visualization in experiments. • Immortalized Lines: Our selection includes immortalized cells, which can be advantageous for extended and consistent experimentation. • Cells from KO Mice: We offer cells from specific knockout (KO) mice, enabling researchers to explore the effects of specific gene disruptions. • Media and other cell culture tools: we offer corresponding media for all the cells that we offer and various tools to aid your cell culture from coatings, supplements to bioreactors. Our commitment to providing top-tier primary cells and related services underscores our dedication to advancing the quality and relevance of your research endeavors. Heart In our diverse cell portfolio, we provide over 900 cell types. Apart from cardiomyocytes and iPS derived cardiomyocytes, we also isolate endothelial cells, preadipocytes, myocytes, epithelial cells, and fibroblasts from different regions of the heart and from various species. A spectrum of heart-derived cell types, each with distinct characteristics, contributes to diverse realms of cardiovascular research. Cardiomyocytes, the heart's muscle cells, find applications in drug screening, cardiac toxicity assessment, and investigations into cardiac hypertrophy and regeneration. Endothelial cells, lining blood vessels, play a pivotal role in studies related to angiogenesis, atherosclerosis, and vascular inflammation. Preadipocytes, precursors to adipocytes, are integral in research focusing on adipogenesis, obesity-related conditions, and metabolic disorders. Myocytes, whether cardiac or skeletal, are fundamental in deciphering heart function, arrhythmias, and muscular disorders. Epithelial cells, forming the outer layers of the heart and blood vessels, contribute to studies on tissue development, regeneration, and barrier function. Finally, fibroblasts, providing structural support, are indispensable in exploring fibrosis, extracellular matrix dynamics, and tissue repair mechanisms. This diverse array of heart-derived cells collectively propels advancements in cardiac biology, offering insights into development, function, and pathology, with applications spanning from basic research to therapeutic development and regenerative medicine. 13 Scan the QR code to see our full cell list.