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Şizofrenide Obezite Nedenleri<br />

Low physical<br />

activity<br />

Poor food choices<br />

Dysfunctional<br />

reward<br />

mechanisms<br />

Severe mental<br />

illness<br />

Hypercortisolaemia<br />

Low IGF­I<br />

Low birth Social<br />

weight environment<br />

Person with<br />

severe mental<br />

illness<br />

Obesity<br />

Antipsychotics<br />

Genetic<br />

polymorphisms<br />

↑ Appetite<br />

↓ Basal metabolic rate (?)<br />

Sedation<br />

Altered physical activity<br />

The development of obesity in serious mental illness results from the complex<br />

interaction of the genotype and environment of the person with mental illness, the<br />

mental illness itself and antipsychotic medication. IGF IGF­1, Insulin­like growth factor­1<br />

Diabetes, Obesity and Metabolism, 11, 2009, 665 665–679

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