Akademischer Bericht 2005 - Geburtshilfe - UniversitätsSpital Zürich

cortisol. Since IUGR is one of the most important consequences of preeclampsia, the data obtained will
also be valid for IUGR in preeclampsia. The role of the isoenzyme type 1 (111b-HSD1) as well as the
tissue origin (maternal, fetal)of both enzymes in human placenta are not clear.
Aims: The questions we thus wish to answer are: which isoenzyme activity is impaired or conserved in
which cells of the placenta at which gestational age and wihich condition(normal/pathological)
Endpoints: 11b-HSD1/2 expression and activity/function in human placenta with respect to tissue origin
(mother/fetus), gestational age (longitudinally in pregnancy and at delivery), and clinical status (normal
pregnancy vs IUGR/preeclamptic pregnancy and gestational diabetes resp..
01.11.2003-31.12.2006
Professur/Forschungsbereich: Zisch, Andreas
Abnormal placental invasion: a single center sequence
A retrospective review of the records of the deliveries in 1999-2003 at the Department of Obstetrics, University
Hospital Zurich respect to abnormal placentation was conducted and the incidence, risk factors
and outcome were observed.
01.02.2004-28.02.2005
Professur/Forschungsbereich: Zisch, Andreas
Analysis of the Hypothalamus-Pituitary-Adrenal System in the concept of fetal programming.
01.01.2005-31.05.2006
Professur/Forschungsbereich: Zisch, Andreas
Analysis of the sympathetic system in the concept of fetal programming
01.01.2005-31.05.2006
Professur/Forschungsbereich: Zisch, Andreas
Bioavailability of dietary iron during pregnancy
The administration of a defined amount of stable iron isotopes (57Fe and 58Fe) enables us to differentiate
between iron already circulating in the human body and iron absorbed from the gut. This method
is used in a longitudinal study to determine the bioavailibility of nutritional iron, the distribution of iron in
materno-fetal circulation and iron metabolism during pregnancy.
Recruited are women with sufficient iron stores defined by a haemoglobin of = 12 g/dl and a serum
ferritin of = 40 ţg/l at the initial stage of their pregnancy (max. 10 GW). Medical history and precise
evaluation of eating habits during pregnancy are filed in detail. Recruited patients are asked not to take
any iron supplements during pregnancy. After a fasting period of 9 - 12 hours patients then receive 3 mg
of the isotope 57Fe orally (in a piece of bread) and 10 minutes later a single i.v. injection of 0.5 mg of
the isotope 58Fe as iron sucrose.
Oral 57Fe administrations are repeated once in the second and once in the third trimenon. Blood samples
are taken immediately prior to each oral administration as well as 14 days later, and then every three
or four weeks (i.e. until the next trimenon or until delivery). Each time, iron status, haematological changes
including parameters of infection, total iron content of whole blood samples and the iron isotope
composition are assessed. Total iron content is measured by atomic absorption spectrophotometry and
isotope composition by negative thermal ionization mass spectrometry.
01.09.1998-30.11.2005
Professur/Forschungsbereich: Zisch, Andreas
Bioengineered closure devices for the healing of PPROM
Premature preterm rupture of the fetal membranes (PPROM; deutsch: der frühe vorzeitige Fruchtblasensprung)
defines the rupture of the chorioamniotic membrane before the onset of labor. Spontaneous
PPROM represents a frequent, often devastating obstetrical complication that accounts for 30 to 40 percent
of preterm deliveries. In Switzerland, £1200 of total 80 000 annual pregnancies are affected, and
millions worldwide. There is currently no treatment capable of sealing the fetal membranes in patients
with spontaneous PPROM.
The objective of the proposed research is to develop a clinically practical closure device that can be
fetoscopically applied to seal focal lesions in the amniotic membrane caused by spontaneous PPROM.
Klinik für Geburtshilfe
Akademischer Bericht 2005
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