Akademischer Bericht 2005 - Geburtshilfe - UniversitätsSpital Zürich

Professur/Forschungsbereich: Zisch, Andreas
Risks of Long-QT syndrome in the Neonate
Evaluation eines möglichen (dosisabhängigen) Zusammenhangs zwischen einer Methadonsubstitution
zur Behandlung der Opiatabhängigkeit während der Schwangerschaft und dem Auftreten von QT-
Verlängerungen im EKG des Neugeborenen.
01.08.2005-28.02.2007
Professur/Forschungsbereich: Zisch, Andreas
Screening for hemoglobinopathies in pregnancy.
01.01.2003-31.12.2006
Professur/Forschungsbereich: Zisch, Andreas
Selective use of erythropoietin (rhEPO) and iron sucrose in severe postpartum anaemia with special
emphasis on the postpartal inflammatory reaction
With a prevalence of 4-10% the postpartum anaemia is a main reason of morbidity of young women.
Reasons for this are not only the blood loss but also the depletion of the iron stores during pregnancy, the
loss of the mobil iron reservoir postpartum and the elevated inflammatory parameters influencing the iron
metabolism. It is known that especially operative delivery leeds to a systemic inflammatory response. In
former studies we were able to show a suppressed erythropoietin production and inadaequate response
to rhEPO. The aim of this study is to determine, whether women with severe bleeding anaemia (Hb < 8.5
g/dL) show suppressed EPO levels due to enhanced inflammatory response and how they profit of an
additional rhEPO therapy. Parameters as erythrocyte and reticulocyte indices, serum iron, transferrin,
ferritin, soluble transferin receptors, erythropoietin, CRP, IL-6, IL-8 and Neopterin where analysed on
day 1, 4, 8, and 15.
01.03.1999-31.05.2005
Professur/Forschungsbereich: Zisch, Andreas
Selective use of erythropoietin (rhEPO) in anemic pregnant women with heterozygous form of hemoglobinopathies
01.02.2004-31.08.2005
Professur/Forschungsbereich: Zisch, Andreas
Selective use of recombinant human EPO in pregnant patients with anaemia, non responsive to iron
therapy only (oral and parenteral) or with severe anaemia at diagnosis
Introduction: We intend to examine a new therapy regimen for the use of parenteral iron sucrose and
human recombinant erythropoietin (rhEPO) in pregnancy to women with a proven iron deficiency anaemia
(IDA) [ferritin < 15 g/L, CRP = 10 mg/L]. For controlling the benefit we measure beside the classical
parameters as erythrocyte and reticulocyte indices, serum iron, transferrin, ferritin, CRP and erythropoietin
level, in addition two new parameters of iron diagnostic, neopterin and serum transferrin receptors
(s-TfR). Neopterin is released from macrophages when cellular immune resistance is activated by cytokines.
It is considered an indirect marker for iron metabolism disorders. The s-TfR is a new parameter
which is purported to detect iron deficiency. The combination of both neopterin and s-TfR might result
in improved diagnosis of the iron status, respectively, of anaemia, and thus also influence the therapy
strategy. summary: To examine (1) a new therapy regimen women are an indicator of insufficient iron
mobilisation /erythropoiesis, and (3) how reliably the s-TfR detect IDA in pregnancy.
01.01.1998-31.05.2005
Professur/Forschungsbereich: Zisch, Andreas
Side-effects of Adalat Tokolysis
01.01.2004-31.03.2005
Professur/Forschungsbereich: Zisch, Andreas
Simulation of course of delivery with ’Ana-Pelvis’ computer program using ultrasound fetal biometry and
MRI pelvimetric data.
01.06.2003-30.06.2006
Klinik für Geburtshilfe
Akademischer Bericht 2005
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