Akademischer Bericht 2005 - Geburtshilfe - UniversitätsSpital Zürich

Secondary endpoints: ferritin (prior to delivery); hemoglobin (day 3 after delivery); gestational age at
delivery, birth weight, anemic treatment requirements, length of hospitalisation after delivery.
01.05.2003-31.12.2006
Professur/Forschungsbereich: Zisch, Andreas
Efficacy of intravenously administered Venofer versus oral Tardyferon in the prophylaxis of iron deficiency
anaemia in pregnant women
01.01.2004-30.11.2005
Professur/Forschungsbereich: Zisch, Andreas
EURAP: European register for pregnancies with antiepileptic drugs
To describe in a prospective study the risk of teratogen effects of antiepileptic drugs.
01.10.2003-31.12.2008
Professur/Forschungsbereich: Zisch, Andreas
Evaluation of fetal intracardiac function using pulsed Doppler
Introduction: Cardiac activity is the driving force for circulation. Therefore we intend to evaluate right and
left ventricular function and correlate these findings with perpheral Doppler indices.
Patients: In order to establish reference values for right and left cardiac output as well as peak aortic and
pulmonary velocity 200 normal fetuses equally distributed over the gestational age range from 24 to 41
weeks were examined.
Results: According to standard statistics for age-dependent variables reference ranges for 5th, 50th and
95th percentile were calculated.
Conclusion: These reference ranges are the basis for the evaluation of fetuses with intrauterine growth
retardation.
01.01.2002-31.12.2005
Professur/Forschungsbereich: Zisch, Andreas
Evaluation of gustatory and olfactory function in pregnancy
The aim of the study was to evaluate gustatory and olfactory function in 53 pregnant women and 59 nonpregnant
women by a validated olfactory and validated taste test. In addition, we investigated whether
nausea and vomiting and olfactory sensitivity are correlated. We determined whether subjects with little
or no nausea and vomiting are less sensitive to odours than subjects who indicate a high degree of
nausea and vomiting, and whether subjects with relatively low olfactory sensitivity are less prone to
nausea and vomiting than subjects with relatively higher olfactory sensitivity.
01.09.1999-30.06.2005
Professur/Forschungsbereich: Zisch, Andreas
Fetal membranes
Objectives - To prepare a tissue engineering approach to fetal membrane repair after premature rupture
of the membranes (PROM) by characterizing the proliferation potential of human amnion epithelial and
mesenchymal cells from preterm and term placenta in primary culture.
- To compare ‘wound healing’ by human amnion epithelial and mesenchymal cells from preterm and
term placenta using an in vitro lesion repair assay.
- To examine the influence of extracellular matrix molecules on the in vitro lesion repair by human amnion
epithelial and mesenchymal cells
- To prepare a human amnion scaffold for repair of PROM
- To study the viscoelastic properties of amnion membranes compared to gestational age
01.05.2000-31.07.2005
Professur/Forschungsbereich: Zisch, Andreas
Imunologic-predictive markers of preeclampsia
Preeclampsia occurs in 5% of all pregnancies and is one of the major reasons for both maternal and fetal
morbidity and mortality. The origin of preeclampsia is unknown, however, it is thought that an imunologic
maladaptation between mother and fetus contributes significantly to the manifestation of the disease.
Women with imunological diseases s.a. Lupus erythematodes and Antiphospholipid-Syndrome are at
Klinik für Geburtshilfe
Akademischer Bericht 2005
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