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CHUNG, SOONKYU, Ph. D. Mechanisms b
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MECHANISMS BY WHICH CONJUGATED LINO
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APPROVAL PAGE This Dissertation has
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I also would like to thank The Univ
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IV. PREADIPOCYTES MEDIATE LPS-INDUC
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LIST OF FIGURES ix Page Figure 1.1.
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Figure 4.7. LPS-induced NFκB activ
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in animals and some humans (reviewe
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CLA is potentially effective in: 1)
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Anti-adipogenic Mechanisms of CLA T
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2005). Chapter II of this dissertat
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Figure 1. 2. Multiple mechanisms by
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In contrast, studies conducted in a
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activation. Similarly, Chen et al.
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Central Hypothesis and Specific Obj
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CHAPTER II TRANS-10, CIS-12 CLA INC
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of MEK/ERK signaling by trans-10, c
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Materials and Methods Materials All
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the cultures for additional 12 h. A
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- Page 41 and 42: or for 30 min with 10 µM isoproter
- Page 43 and 44: either 30 µM cis-9, trans-11 CLA o
- Page 45 and 46: dependent effects of CLA on the pho
- Page 47 and 48: Rapamycin Blocks CLA’s Increase i
- Page 49 and 50: Figure 2. 2. Trans-10, cis-12 CLA a
- Page 51 and 52: Figure 2. 4. Trans-10, cis-12 CLA a
- Page 53 and 54: Figure 2. 6. Trans-10, cis-12 CLA i
- Page 55 and 56: Figure 2. 8. Trans-10, cis-12 CLA-i
- Page 57 and 58: Discussion Feeding mixed CLA isomer
- Page 59 and 60: in lipolysis may occur via an ERK-d
- Page 61 and 62: espectively, by the MEK inhibitor U
- Page 63 and 64: Furthermore, the CLA-mediated incre
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- Page 67 and 68: Sopasakis et al. 2004) and insulin
- Page 69 and 70: antibodies for anti-glyceraldehydre
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- Page 73 and 74: were (accession #NM000600) sense (5
- Page 75 and 76: Transfection efficiency was examine
- Page 77 and 78: treatment (Brown et al. 2004), we d
- Page 79 and 80: myotubes (Sinha et al. 2004; Weiger
- Page 81 and 82: controls was found in cytosol (Fig
- Page 83 and 84: Depletion of NFκB p65 by RNAi Atte
- Page 85 and 86: eports of cytokine-mediated insulin
- Page 87 and 88: Figure 3. 2. Trans-10, cis-12 CLA i
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- Page 93 and 94: Figure 3. 8. Specific depletion of
- Page 95 and 96: Figure 3. 10. Working model: Trans-
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- Page 99 and 100: mRNA levels of TNF-α (Fig. 3). How
- Page 101 and 102: humans (Riserus et al. 2004a), and
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- Page 105 and 106: 1) decreased adipogenic gene expres
- Page 107 and 108: adipocytes from WAT in inflammation
- Page 109 and 110: differentiation, cultures of SV cel
- Page 111 and 112: Immunoblotting and 4MUrea-SDS-PAGE
- Page 113 and 114: activity was measured using the Dua
- Page 115 and 116: macrophages and myocytes, respectiv
- Page 117 and 118: cultures, insulin’s stimulation o
- Page 119 and 120: AD90 cultures treated with LPS. Con
- Page 121 and 122: Table 4.1. List of human-gene speci
- Page 123 and 124: Figure 4.2. Primary cultures of new
- Page 125 and 126: Figure 4.4 LPS induction of cytokin
- Page 127 and 128: Figure 4. 6. LPS suppresses PPARγ
- Page 129 and 130: Figure 4. 8. Inhibitors of NFκB at
- Page 131 and 132: Discussion Adipose tissue is a sour
- Page 133 and 134: To determine if non-adipocytes othe
- Page 135 and 136: attenuation of insulin sensitivity
- Page 137 and 138: epression of NFκB target gene expr
- Page 139 and 140: EPILOGUE The “Obesity epidemic’
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Apart from our initial goal for thi
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Concerning membrane specific recept
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esearch topic I would like to exami
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Berg, A.H., Lin, Y., Lisanti, M.P.,
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Chen, C., Koh, A.J., Datta, N.S., Z
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Diradourian, C., Girard, J., and Pe
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Granlund, L., Juvet, L.K., Pedersen
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Imamura, M., Inoguchi, T., Ikuyama,
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Loscher, C.E., Draper, E., Leavy, O
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Piper, R.C., Hess, L.J., and James,
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Sinha, S., Perdomo, G., Brown, N.F.
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Vanden Berghe, W., Vermeulen, L., D