Curriculum Vitae

Bone metastases research
Research topic(s):
1. RANK ligand and osteoprotegerin as mediators of metabolic bone diseases
2. Molecular pathogenesis of skeletal metastases
3. Myeloma bone disease
Group leader(s):
Prof. Dr. med. Lorenz Christian Hofbauer
Department of Medicine III
Division of Endocrinology/Diabetes/Bone Diseases
Technical University Medical Center
Fetscherstrasse 74
01307 Dresden
Ph: +49-351-458-3173
Fax: +49-351-458-4309
E-mail: lorenz.hofbauer@uniklinikum-dresden.de
Education:
1987 Abitur, Johannes-Nepomuk-Gymnasium, Rohr
1988-1994 Medical School, University of Munich, Germany
1995 Medical thesis, University of Munich, Dr. med.
1996 US Medical license, Educational Commission for Foreign Medical
Graduates
2002 Habilitation, Internal Medicine
2003 Board Certification, Internal Medicine
2004 Board Certification, Endocrinology, Certification, Diabetes „DDG“,
German Diabetes Society
2005 Board Certification, Sports Medicine, Certification, Osteology „DVO“,
German Bone Society
2008 Board Certification, Gastroenterology
Training:
1995-1996 Residency, Department of Medicine, University of Munich
1996-1999 Research Fellowship, Endocrine Research Unit, Division of
Endocrinology, Mayo Clinic, Rochester, USA
1999-2003 Residency, Department of Medicine, Philipps-University, Marburg,
Germany
2004 Associate Consultant, Department of Medicine, Philipps-University,
Marburg,
2005 Consultant, Department of Medicine, Philipps-University, Marburg,
Clinical Experience:
Internal medicine, endocrinology, diabetes, bone diseases, endocrine, neuroendocrine and
bone tumors.
Professional Appointments:
2007 Professor of Medicine and Head, Division of Endocrinology, Diabetes,
Bone Diseases, Department of Medicine, Technical University,
Dresden
Publications: 150 scientific publications in peer reviewed journals
Funding: Extrabudgetary funding by DFG, Sander Foundation, Elsbeth Bonhoff
Foundation, Novartis Foundation.
Awards: John Haddad Young Investigator’s Award of the American Society of
Bone and Mineral Research; Merck Senior Fellows Award of the
Endocrine Society, Edward C. Kendall Alumni Science Award for
Meritorious Basic Research, Mayo Clinic, EJE Prize, DVO research
group award.
Stand: 07.04.2011

Journals: Reviewer for Lancet, Science, Blood, JBMR, JCEM and others.
Grant review: DFG, Swiss National Fonds, FWF Austria.
Societies: Member Endocrine Society, American Society of Bone and Mineral
Research, German Endocrine Society.
Group members:
Scientists: Claudia Göttsch, PhD; Martina Rauner, PhD
PhD students: Peggy Benad, MA; Sylvia Thiele, MA; Kathrin Sinningen; MA, Juliane
Salbach, MA; Yvonne Höhna, MA
Internal collaborators:
M. Bornhäuser, M. Wobus, Department of Medicine I
M. Wirth, S. Füssel, Department of Urology
S. R. Bornstein, G. Eisenhofer, Department of Medicine III
K.-P. Günther, Department of Orthopedics
S. Rammelt, Department of Trauma Surgery
External collaborators:
R. Erben, University of Veterinary Medicine, Vienna, Austria
F. Jakob, Prof. Dr. N. Schütze, Department of Orthopedics, University of Würzburg
C.-C. Glüer, University of Kiel
H. Kalthoff, Institute of Experimental Tumor Research, University of Kiel
R. Bargou, Division of Hematology and Internal Oncology, University of Würzburg
I. Nakchbandi, Division of Molecular Medicine, Max-Planck-Institute Munich
M. Schoppet, V. Ellenrieder, N. Al-Fakhri Philipps-University, Marburg
Participation in collaborative research projects (local, national, international):
SkelMet Forschergruppe initiative (Dresden-Kiel-Munich-Würzburg) will be decided in July
2011
DFG-Transregio 67 (Dresden-Leipzig)
List of ten most important publications 2005-2011:
1. Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet (2011) in press.
2. Hofbauer LC, Rachner TD, Hamann C. From bone to breast and back – the bone cytokine RANKL
and breast cancer. Breast Cancer Res (2011) in press.
3. Thiele S, Rauner M, Goettsch C, Rachner TD, Benad P, Fuessel S, Erdmann K, Hamann C,
Baretton GB, Wirth MP, Jakob F, Hofbauer LC. J Cell Biochem (2011) in press.
4. Hofbauer LC, Jakob F, Felsenberg D. Bisphosphonates and atypical femoral fractures. N
Engl J Med (2010) 363: 1084-1085.
5. Rachner TD, Benad P, Rauner M, Goettsch C, Singh SK, Schoppet M, Hofbauer LC.
Osteoprotegerin production by breast cancer cells is suppressed by dexamethasone and confers
resistance against TRAIL-induced apoptosis. J Cell Biochem (2009) 108: 106-116.
6. Rachner TD, Singh SK, Schoppet M, Benad P, Bornhäuser M, Ellenrieder V, Ebert R, Jakob F,
Hofbauer LC. Zoledronic acid Induces apoptosis and changes the TRAIL/OPG ratio in breast
cancer cells. Cancer Lett (2009) 287: 109-116.
7. Hofbauer LC, Miehlke S. More on reports of esophageal cancer with oral bisphosphonate use. N
Engl J Med (2009) 360: 1790.
8. Rachner TD, Schoppet M, Niebergall U, Hofbauer LC. 17beta-Estradiol inhibits osteoprotegerin
production by the estrogen receptor-alpha-positive human breast cancer cell line MCF-7. Biochem
Biophys Res Commun (2008) 368: 736-741.
9. Hofbauer LC, Rachner T, Singh SK. Fatal attraction: why breast cancer cells home to bone. Breast
Cancer Res (2008) 10: 101.
10. Heider U, Hofbauer LC, Zavrski I, Kaiser M, Jakob C, Sezer O. Novel aspects of osteoclast
activation and osteoblast inhibition in myeloma bone disease. Biochem Biophys Res Commun
(2005) 338: 687-693.
Stand: 07.04.2011