Pancreatic Cancer Research Research topic(s): Development of ...

Pancreatic Cancer Research
Research topic(s):
Development of new concepts for diagnosis and therapy of pancreatic adenocarcinoma
Group leader(s):
PD Dr. phil. nat. Christian Pilarsky
Department of Visceral-, Thoracic- and Vascular Surgery
University Hospital Dresden
Fetscherstraße 74
01307 Dresden
Phone: +49-351-458 7020
Fax: +49-351-458 7338
E-mail: Christian.Pilarsky@uniklinikum-dresden.de
Education:
1983-1988 Study of Biology in Frankfurt M. with grade "sehr gut"
2005 Habilitation in Experimental Surgery at the University of Dresden
Training:
1990-1994 Doctoral thesis in Frankfurt M. with grade "magna cum laude"
Professional Appointments:
1993-1997 Group leader in the Dept. of Urology, University Dresden
1997-2002 Group leader at metaGen Pharmaceuticals
since 2002 Group leader in the Dept. of Surgery, University Dresden
Publications: ~80 scientific publications in peer reviewed journals
Funding: Extrabudgetary funding by DFG, Deutsche Krebshilfe, SMWK, Wilhelm
Sander Stiftung
Journals: Reviewer for Oncogene, Cancer Res., J Cell Mol. Med. and others
Grant review: DFG, NIH
Prof. Dr. med. Robert Grützmann, MBA
Department of Visceral-, Thoracic- and Vascular Surgery
University Hospital Dresden
Fetscherstraße 74
01307 Dresden
Phone: +49-351-458 2742
Fax: +49-351-458 4395
E-mail: Robert.Gruetzmann@uniklinikum-dresden.de
Education:
1988-1997 Study of Medicine in Berlin
2005 Habilitation in Surgery at the University of Dresden
2008-2011 Master in Health Care Management
Training:
1997-2002 Clinical training in surgery, University Dresden
Research Experience:
1995-1997 Doctoral thesis in Berlin
since 2002 Group leader together with PD Pilarsky in the Dept. of Surgery, University
Dresden
Professional Appointments:
1997 Visiting Associate Boston Consulting Group
1997-2006 Department of Surgery, University hospital Dresden
Since 2006 Group leader pancreatic surgery University hospital Dresden
2010 Professor of Surgery, University hospital Dresden
Stand: 08.04.2011

Publications: ~70 scientific publications in peer reviewed journals
Funding: Extrabudgetary funding by DFG, Deutsche Krebshilfe
Awards: von-Langenbeck-Preis der Deutschen Gesellschaft für Chirurgie 2005
Young Investigator Award: 11th Meeting of the International Association of
Pancreatology and the 35th Annual Meeting of the Japan Pancreas
Society 2004 (Sendai, Japan)
Journals: Cancer Detection and Prevention;European Journal of Cancer; Oncogene;
Annals of Surgery, Cancer Research, GUT
Grant review: Associazione Italiana per la Ricerca sul Cancro
Societies: Association of Academic Surgery (USA), Deutsche Gesellschaft für
Allgemein und Viszeralchirurgie, Deutsche Gesellschaft für Chirurgie
(DGCH), Deutscher Pankreasclub, Mitteldeutsche Chirurgenvereinigung,
Pancreas Club (USA), Sektion Chirurgische Forschung der Deutschen
Gesellschaft für Chirurgie
Group members:
Scientists: Dr. Axel Denz, Dr. Felix Rückert, Dr. Marius Distler, Kristin Werner, Diana
Wehrum, Carolin Zimmermann
MD Students: Nicole Samm, Petra Mattheschke, Iris Böhme, Katja Biewusch, Marie
Heyne, Maria Schneider, Vera Hentrich, Tobias Gorille
Internal collaborators:
Michael Bachmann, Institute of Immunology
Nils Cordes, Oncoray
Gustavo Baretton, Institute of Pathology
Michael Schröder, Institute for Bioinformatics
External collaborators:
Holger Kalthoff, Dept. of Molecular Oncology, University of Schleswig- Holstein
Glen Kristiansen, Institute of Pathology, University Zürich
Markus Büchler, Dept. of Surgery, University of Heidelberg
David Tuveson, Tumour Modelling & Experimental Medicine, Cambridge Research Institute
Participation in collaborative research projects (local, national, international):
Roland-Ernst Stiftung für Gesundheitswesen: Gene expression profiling for the prediction of
pancreatic cancer patients survival (national)
Deutsche Forschungsgemeinschaft: The role of SFRP1 in pancreatic cancer metastasis
(national)
List of ten most important publications 2005-2011:
1. Ehehalt F, Rümmele P, Kersting S, Lang-Schwarz C, Rückert F, Hartmann A, Dietmaier W,
Terracciano L, Aust D, Jahnke B, Saeger HD, Pilarsky Ch, Grützmann R (2011) Hepatocyte
nuclear factor (HNF) 4α Expression distinguishes Ampullary Cancer Subtypes and Prognosis after
Resection. Ann Surg accepted
2. Olive K P, Jacobetz M A, Davidson C J, Gopinathan A, McIntyre D, Honess D, Madhu B,
Goldgraben M A, Caldwell M E, Allard D, Frese K K, Denicola G, Feig C, Combs C, Winter S P,
Ireland H, Reichelt S, Howat W J, Chang A, Dhara M, Wang L, Ruckert F, Grutzmann R, Pilarsky
C, Izeradjene K, Hingorani S R, Huang P, Davies S E, Plunkett W, Egorin M, Hruban R H,
Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson D A (2009)
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of
Pancreatic Cancer. Science 324: 1457-61.
3. Kersting S, Konopke R, Kersting F, Volk A, Distler M, Bergert H, Saeger H D, Grützmann R, Bunk
A (2009). Quantitative Perfusion Analysis of Contrast-Enhanced Ultrasonography to Distinguish
Pancreatic Carcinomas from Pancreatitic Masses. Gastroenterology accepted.
4. Matos J M, Schmidt C M, Turrini O, Agaram N P, Niedergethmann M, Saeger H D, Merchant N,
Johnson C S, Lillemoe K D, Grützmann R (2009) Pancreatic acinar cell carcinoma: a multiinstitutional
study. J Gastrointest Surg 13:1495-502.
Stand: 08.04.2011

5. Grutzmann R, Molnar B, Pilarsky C, Habermann J K, Schlag P M, Saeger H D, Miehlke S, Stolz T,
Model F, Roblick U J, Bruch H P, Koch R, Liebenberg V, Devos T, Song X, Day R H, Sledziewski
A Z, Lofton-Day C (2008) Sensitive detection of colorectal cancer in peripheral blood by septin 9
DNA methylation assay. PLoS ONE 3: e3759.
6. Ruckert F, Hennig M, Petraki C D, Wehrum D, Distler M, Denz A, Schroder M, Dawelbait G,
Kalthoff H, Saeger H D, Diamandis E P, Pilarsky C, Grutzmann R (2008) Co-expression of KLK6
and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma. Br J Cancer
99: 1484-92.
7. Pilarsky C, Ammerpohl O, Sipos B, Dahl E, Hartmann A, Wellmann A, Braunschweig T, Lohr M,
Jesnowski R, Friess H, Wente M N, Kristiansen G, Jahnke B, Denz A, Ruckert F, Schackert H K,
Kloppel G, Kalthoff H, Saeger H D, Grutzmann R (2008) Activation of Wnt signalling in stroma
from pancreatic cancer identified by gene expression profiling. J Cell Mol Med 12: 2823-35
8. Kristiansen G, Jacob J, Buckendahl A C, Grutzmann R, Alldinger I, Sipos B, Kloppel G, Bahra M,
Langrehr J M, Neuhaus P, Dietel M, Pilarsky C (2006) Peroxisome proliferator-activated receptor
gamma is highly expressed in pancreatic cancer and is associated with shorter overall survival
times. Clin Cancer Res 12: 6444-51.
9. Grutzmann R, Boriss H, Ammerpohl O, Luttges J, Kalthoff H, Schackert H, Kloppel G, Saeger H,
Pilarsky C (2005). Meta-analysis of microarray data on pancreatic cancer defines a set of
commonly dysregulated genes. Oncogene 24, 5079-5088.
10. Herr A, Grutzmann R, Matthaei A, Artelt J, Schrock E, Rump A, Pilarsky C (2005). Genomic
profiling using high density oligonucleotide arrays. Genomics 85, 392-400.
Stand: 08.04.2011