Hematology and Oncology Research topics: Leukemia, stem cell ...

Hematology and Oncology
Research topics:
Leukemia, stem cell biology and haematopoietic blood stem cell transplantation
Group leader:
Prof. Dr. Gerhard Ehninger
Department of Internal Medicine I
University Hospital Carl Gustav Carus
Technische Universität Dresden
Fetscherstraße 74
01307 Dresden
Phone: + 49-351- 458 4190
Fax: +49-351- 458 5362
E-mail: Gerhard.Ehninger@uniklinikum-dresden.de
Education:
1971: University Tübingen
1976 - 1978: Doctoral Thesis
7/1985: Habilitation
8/1985: Registration for Internal Medicine
10/1985: Venia legendi at the Eberhard-Karls-Universität, Tübingen
2/1988: Additional degree in hematology and oncology
5/1991: Founder partner of the German Bone Marrow Registry (non-profit
organization)
10/1991: Associate professor
10/1994 C4 professorship for Internal Medicine
Training:
8/1978-9/85: Internship and residency, Internal Medicine, Department of Hematology,
Oncology, Rheumatology and Immunology, Tübingen
10/1985: Senior physician, Internal Medicine, Tübingen, and Head of the
transplantation program
Clinical Experience:
Internal medicine, diagnostic and medical treatment of cancers and leukemias
Professional Appointments:
since 1994 Director (Internal Medicine I, University Hospital, Dresden)
since 2003 Chair UCC (since 2010 executive chair, MF, UKD)
Publications: 501 publications in scientific journals (aus CK DKTK)
Funding: Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe, BMBF, State of
Saxony, Industry
Award: International Red Cross Science Award
Journals: Reviewer for New England Journal of Medicine, Blood, DMW, Annals of
Hematology
Grant review: Deutsche Forschungsgemeinschaft, Deutsche Krebshilfe
Societies: Chairman of the DGHO Deutsche Gesellschaft für Hämatologie und
Onkologie (German Society of Haematology and Oncology), Speaker of the
SFB 655 “Cells into tissues”, American Society for Clinical Oncology,
American Society of Hematology, Deutsche Arbeitsgemeinschaft für
Knochenmark- und Blutstammzelltransplantation (German Hematopoietic
Stem Cell Transplantation Group),
Group members:
Staff of Internal Medicine I
Internal collaborators:
Stand: 08.04.2011

Michael Baumann, University Cancer Center, Department of Radiation Oncology
Michael Bachmann, Immunology
Hans-Detlev Saeger, Department of Surgery
Gustavo Baretton, Institute of Pathology
Manfred Wirth, Department of Urology
External collaborators:
Max-Planck-Institute for Cell Biology and Genetics
Study Alliance Leukemia Centers (9 university hospital, 44 community hospital, 10 outpatient
institutions
Fred Hutchinson Cancer Research Center, Seattle, USA
Participation in collaborative research projects (local, national, international):
SFB 655, Cells into tissues; Forschungszentrum 111, Regenerative Therapies: "From cells to
tissues to therapiesengineering the cellular basis of regeneration"
Competence Network Leukemia
National Marrow Donor Program (USA)
Euronet
List of ten most important publications 2005–2011:
1. Röllig C, Bornhäuser M, Thiede C, Taube F, Aulitzky W, Bodenstein H, Tischler H, Stuhlmann R,
Kramer M, Mohr B, Schuler U, Stölzel F, von Bonin M, Wandt H, Schäfer-Eckart K, Schaich M, and G
Ehninger. Long-term prognosis of acute myeloid leukemia according to the new genetic risk
classification of the European LeukemiaNet recommendations: Evaluation of the proposed reporting
system in a cohort of 1557 patients. J Clin. Oncol. (2011), in press
2. Schaich M, Röllig C, Soucek S, Kramer M, Thiede C, Mohr B, Oelschlaegel U, Schmitz N, Stuhlmann
R, Wandt H, Schäfer-Eckart K, Aulitzky W, Kaufmann M, Bodenstein H, Tischler J, Ho A, Krämer A,
Bornhäuser M, Schetelig J, and G Ehninger. Cytarabine dose of 36 g/m² versus 12 g/m² within first
consolidation in acute myeloid leukemia: Results of 933 patients enrolled in the prospective
randomized AML96 study. J Clin. Oncol. (2011), in press
3. Röllig C, Thiede C, Gramatzki M, Aulitzky W, Bodenstein H, Bornhauser M, Platzbecker U,
Stuhlmann R, Schuler U, Soucek S, Kramer M, Mohr B, Oelschaegel U, Stolzel F, Von B M, Wermke
M, Wandt H, G Ehninger, Schaich M (2010). A novel prognostic model in elderly patients with acute
myeloid leukemia - results of 909 patients entered into the prospective AML96 trial. Blood: 971-978.
4. Ehninger G, Schmidt AH (2009). Putting insulin glargine and malignancies into perspective.
Oncologist. 14: 1169-1174.
5. K. Holig, M. Kramer, F. Kroschinsky, M. Bornhauser, T. Mengling, A. H. Schmidt, C. Rutt, and G
Ehninger, Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in
unrelated volunteers: 12 years of single-center experience in 3928 donors, Blood, 114 (2009) 3757-
3763.
6. D. Confer, R. Gress, M. Tomblyn, and G. Ehninger, Hematopoietic cell graft safety, Bone Marrow
Transplant., 44 (2009) 463-465.
7. E. Goekkurt, S. E. Al-Batran, J. T. Hartmann, U. Mogck, G. Schuch, M. Kramer, E. Jaeger, C.
Bokemeyer, G. Ehninger, and J. Stoehlmacher, Pharmacogenetic analyses of a phase III trial in
metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin
or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie, J. Clin. Oncol., 27 (2009)
2863-2873.
8. A. Lauter, A. Strumpf, U. Platzbecker, J. Schetelig, M. Wermke, J. Radke, A. Kiani, G. Wunderlich, C.
Thiede, G. Ehninger, J. Kotzerke, and M. Bornhauser, (188)Re anti-CD66 radioimmunotherapy
combined with reduced-intensity conditioning and in-vivo T cell depletion in elderly patients
undergoing allogeneic haematopoietic cell transplantation, Br. J. Haematol., (2009).
9. J. Schetelig, M. Bornhauser, C. Schmid, B. Hertenstein, R. Schwerdtfeger, H. Martin, M. Stelljes, U.
Hegenbart, K. Schafer-Eckart, M. Fussel, B. Wiedemann, C. Thiede, J. Kienast, H. Baurmann, A.
Ganser, H. J. Kolb, and G. Ehninger, Matched unrelated or matched sibling donors result in
comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid
leukemia: a report from the cooperative German Transplant Study Group, J. Clin. Oncol., 26 (2008)
5183-5191.
10. H. Wandt, U. Schakel, F. Kroschinsky, G. Prange-Krex, B. Mohr, C. Thiede, U. Pascheberg, S.
Soucek, M. Schaich, and G. Ehninger. MLD according to the WHO classification in AML has no
Stand: 08.04.2011

correlation with age and no independent prognostic relevance as analyzed in 1766 patients, Blood,
111 (2008) 1855-1861.
Stand: 08.04.2011