Antibody Design Research topic(s): 1. Activation of immune effector ...

Antibody Design
Research topic(s):
1. Activation of immune effector cells against tumor cells with recombinant antibody
derivatives
2. Identification of specific or inducible immunotargets on tumor cells
3. Radio- or chemotherapy-induced expression of target molecules for specific tumor
immunotherapy
Group leader(s):
Prof. Dr. rer. nat. et med. habil. Michael Bachmann
Institute of Immunology
Medical Faculty Carl Gustav Carus
Technical University of Dresden
Fetscherstr. 74
01307 Dresden
Ph.: +49-351-4586530
Fax: +49-351-4586316
E-mail: michael.bachmann@tu-dresden.de
Education:
1976-1981 Study of Pharmacy, Johannes Gutenberg University, Mainz
1981 Ph.D., University, Mainz
1989 Habilitation (Physiological Chemistry), University, Mainz
Research Experience: Immunology, biochemistry, cell biology, molecular genetics,
virology, pharmacy.
Focus areas: Immunotargeting of tumor cells, systemic
autoimmunity.
Professional Appointments:
1997-1999 Professor (APL) of Physiological Chemistry, University, Mainz
1999-2002 R-Associate Member, OMRF, Immunology and Arthritis
Program
since 2003 University-Professor of Immunology (Tumorimmunology),
Institute of Immunology, Medical Faculty, TU Dresden
Publications: > 180 publications in scientific journals and books, of these 130 peer-reviewed
Funding: NIH, OCAST, DFG, BMBF, Thyssen Stiftung, VW Stiftung, Dr. Robert
Pfleger Stiftung, Deutsche Knochenmarkspenderdatei GmbH.
Journals: Reviewer for numerous journals including Nucleic Acids Research, J.
Biological Chemistry, J. Immunology, Gene, and many others.
Grant review: Grant reviewer e.g. for Wellcome Trust (UK).
Awards:
19981 Doctoral thesis, summa cum laude
1989 Boehringer-Ingelheim Prize
1990 Award of the German Society of Cell biology
1990 Bruno-Schuler Prize of the German Society of Rheumatology
1991 Stiftungsprofessur (Stifterverband für die Deutsche Wissenschaft) Robert
1991 Feulgen Award by the Int. Society of Cyto- and Histochemistry Greenberg
1998 scholarships at the OMRF, OK, USA
Societies: German Society of Immunology, German Society of Biochemistry and Cell
Biology.
Group members:
Scientists: Dr. rer. nat. Marc Cartellieri, Dr. rer. nat. Anja Feldmann, Dr. rer. med. Slava
Stamova
PhD Students: Claudia Arndt, Stefanie Koristka, Irene Michalk, Nadja Röber
MD Students: Kristin Röder, Mareike Müller, Franziska Krone, Florian Ludwig, Maria Dimmel
Stand: 08.04.2011

Technicians: Barbara Uteß, Livia Schulze, Christine Gräfe
Internal collaborators:
Martin Bornhäuser, Gerhard Ehninger, Department of Medicine I
Susanne Füssel, Manfred Wirth, Department of Urology
Achim Temme, Department of Neurosurgery
Dirk Lindemann, Jacques Rohayem, Institute of Virology
Michael Baumann, Department of Radiation Oncology
Gustavo Baretton, Institute of Pathology
External collaborators:
Professores Harley J.B., Reichlin M., James J.A., Farris A.D., Centola M., Scofield H.,
OMRF, OK, USA)
Prof. Buyon J. (Children Hospital for Joint Disease,New York)
Professores McCluskey J., Gordon T. (Melbourne, Bedfort Park, Australia)
Professores vanVenroi W.J., Prujn G. (Nijmegen, The Netherlands)
Professor Semsei I. (Debrecen, Ungarn)
Prof. Schäkel K., Department of Dermatology, University of Heidelberg, Germany
Participation in collaborative research projects (local, national, international):
Local: WK BioResponse 03WKR02B (BMBF)
Local: Center for Regenerative Therapies Dresden (DFG)
List of ten most important publications 2005-2010:
1. Stamova, S., Cartellieri, M., Feldmann, A., Bippes, C.C., Bartsch, H., Wehner, R., Schmitz, M.,
von Bonin, M., Bornhäuser, M., Ehninger, G., Rieber, E.P., Bachmann, M. (2011).
Simultaneous engagement of the activatory receptors NKG2D and CD3 for retargeting of
effector cells to CD33-positive malignant cells. Leukemia 18. [Epub ahead of print].
2. Hänsel, A., Günther, C., Ingwersen, J., Starke, J., Schmitz, M., Bachmann, M., Meurer, M.,
Rieber, E.P., Schäkel, K. (2011). Human slan (6-sulfo LacNAc) dendritic cells are inflammatory
dermal dendritic cells in psoriasis and drive strong T(h)17/T(h)1 T-cell responses. J Allergy Clin
Immunol. 127, 787-794.e9.
3. Bippes, C.C., Feldmann, A., Stamova, S., Cartellieri, M., Schwarzer, A., Wehner, R., Schmitz,
M., Rieber, E.P., Zhao, S., Schäkel, K., Temme, A., Scofield, R.H., Kurien, B.T., Bartsch, H.,
Bachmann, M. (2011). A novel modular antigen delivery system for immuno targeting of human
6-sulfo LacNAc-positive blood dendritic cells (SlanDCs). PLoS One 21:e16315.
4. Feldmann, A., Stamova, S., Bippes, C.C., Bartsch, H., Wehner, R., Schmitz, M., Temme, A.,
Cartellieri, M., Bachmann, M. (2011). Retargeting of T cells to prostate stem cell antigen
expressing tumor cells: Comparison of different antibody formats. Prostate 28. [Epub ahead of
print].
5. Wehner, R., Schumacher, P., Bornhäuser, M., Ehninger, G., Schäkel, K., Bachmann, M.,
Schmitz, M. (2010). Acute myeloid leukemia cells fail to activate native human dendritic cells: a
potential mechanism of immune evasion. Leukemia 24, 1965-1967. Epub 2010 Sep 2.
6. Wehner, R., Wehrum, D., Bornhäuser, M., Zhao, S., Schäkel, K., Bachmann, M.P., Platzbecker,
U., Ehninger, G., Rieber, E.P., Schmitz, M. (2009). Mesenchymal stem cells efficiently inhibit the
proinflammatory properties of 6-sulfo LacNAc dendritic cells. Haematologica 94, 1151-1156.
Epub 2009 Jun 22.
7. Dudek, N.L., Maier, S.M., Chen, Z., Mudd, P.A., Mannering, S.I., Jackson, D.C., Zeng, W.,
Keech, C.L., Hamlin,K., Pan, Z., Davis-Schwarz, K., Workman-Azbill, J., Bachmann, M.,
McCluskey J. and Farris, A.D. (2007). T cellepitopes of the La/SS-B autoantigen in humanized
transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*201. Arthritis
Rheum. 56, 3387-3398.
8. Straube, C., Wehner, R., Wendisch, M., Bornhäuser, M., Bachmann, M., Rieber, E.P. and
Schmitz, M. (2007). Bortezomib significantly impairs the immunostimulatory capacity of human
myeloid blood dendritic cells. Leukemia 21, 1464-1471.
9. Bachmann, M., Bartsch, H., Gross, J.A., Maier, S.M., Gross, T., Workman, J., James, J.A.,
Harley, J.B.H., Conrad, K., Schmitz, M., Jung, B., Buyon, J.P., Semsei, I., Farris, A.D., Harley,
Stand: 08.04.2011

J.B. and Rieber, E.P. (2006). Autoimmunity as the result of escape from RNA surveillance. J.
Immunology 177, 1698-1707.
10. Wehner, R., Wendisch, M., Schäkel, K., Bornhäuser, M., Platzbecker, U., Mohr, B., Temme, A.,
Bachmann, M., Rieber, E.P. and Schmitz, M. (2006). Imatinib mesylate does not impair the
immunogenecity of human myeloid blood dendritic cells. Leukemia 20, 1629-1632.
Stand: 08.04.2011