Curriculum Vitae - Universitäts KrebsCentrum Dresden - Technische ...

Experimental Pathology/Angiogenesis I
Research topic(s):
1. Regulation of angiogenesis in tumors
2. Role of hypoxia signaling in tumor progression and metastasis
3. Targeted therapies
Group leader(s):
Prof. Dr. rer.nat. Georg Breier
Department of Pathology
Technische Universität Dresden
Fetscherstraße 74
01307 Dresden
Ph.: +49-351-458 5278
Fax: +49-351-458 5814
E-mail: georg.breier@uniklinikum-dresden.de
Education:
1978 Abitur, Hebel-Gymnasium Schwetzingen
1985 Diploma (Biology), Center for Molecular Biology, University of Heidelberg
1988 PhD in molecular genetics. Supervisor: Prof. Dr. Peter Gruss, University
of Heidelberg
2004 Habilitation in Biochemistry, University of Würzburg
Training:
1985-1987 Ph.D. student, Center for Molecular Biology, University of Heidelberg
1987-1988 Ph.D. student, Department of Molecular Cell Biology, Max Planck
Institute of Biophysical Chemistry, Göttingen
1988-1992 Postdoctoral fellow, Department of Neurochemistry, Max Planck Institute
of Psychiatry, Martinsried
Research Experience:
Experience in molecular cell biology, mouse molecular genetics,
conditional gene targeting, tumor biology, experimental gene therapy,
vascular biology, angiogenesis research
Professional Appointments:
1993-2003 Research group leader, Department of Molecular Cell Biology, Max
Planck Institute of Physiological and Clinical Research, Bad Nauheim
2003-present Professor for Endothelial Cell Biology/Pathology and Head of Research,
Department of Pathology, Technische Universität Dresden
Lecturer in Biology, Faculty of Medicine, Technische Universität Dresden
Publications: More than 80 scientific publications in peer reviewed journals
Funding: Extrabudgetary funding by DFG, BMBF, EU
Award: EU Descartes Prize 2004 finalist
Journals: Reviewer for PNAS, EMBO J, Cancer Research, and others
Grant review: DFG, Cancer Research UK, FWF Austria, Swiss Cancer League, AICR
Society: Member Deutsche Gesellschaft für Zellbiologie
Group members:
Scientists: Dr. Silvia Krakau
PhD students: Antje Kettelhake, Aleksandar Kuzmanov, Ina Prade, Maryam Rezaei
MD students: Anja Methner, Maik-Oliver Müller
Internal collaborators:
Gustavo Baretton, Department of Pathology
Michael Baumann, University Cancer Center, Department of Radiation Oncology
Stand: 29.03.2011

Triantafyllos Chavakis, Medical Clinic III
Leoni Kunz-Schughart, University Cancer Center
Dirk Lindemann, Department of Microbiology
Alexander Storch, Department of Neurology
Daniel Zips, University Cancer Center, Department of Radiation Oncology
External collaborators:
Ralf Adams, Max Planck Institute of Molecular Biomedicine, Münster
Konstantinos Anastassiadis, Biotec, Technische Universität Dresden
Hellmut Augustin, German Cancer Research Center (DKFZ), University Heidelberg
Lena Claesson-Welsh, Uppsala University, Uppsala, Sweden
Elisabetta Dejana, University of Milan, Italy
Peter Friedl, University of Würzburg
Eckhard Lammert, University of Düsseldorf
Dörte Katschinsky, University of Göttingen
Hugo Marti, University of Heidelberg
Francis Stewart, Biotec, Technische Universität Dresden
Dietmar Vestweber, Max Planck Institute of Molecular Biomedicine, Münster
Participation in collaborative research projects (local, national, international):
Deutsche Forschungsgemeinschaft - SPP 1190
Deutsche Forschungsgemeinschaft - Center for Regenerative Therapies Dresden (CRTD)
List of ten most important publications 2005-2011:
1. Klotzsche-von Ameln, A., Muschter, A,, Mamlouk, S.,, Kalucka, J., Prade, I., Franke, K., Rezaei,
M., Poitz, D.M., Breier, G., Wielockx, B. (2011). Inhibition of HIF prolyl hydroxylase-2 blocks tumor
growth in mice through the anti-proliferative activity of Transforming Growth Factor beta. Cancer
Res., 2011 Mar 24. [Epub ahead of print]. *equal contribution
2. Hoelscher, M., Silter, M., Krull, S., von Ahlen, M., Hesse, A., Schwartz, P., Wielockx, B., Breier,
G., Katschinski, D.M., Zieseniss, A. (2011). Cardiomyocyte-specific Prolyl-4-hydroxylase domain 2
knock out protects from acute myocardial ischaemic injury. J. Biol. Chem., 2011 Jan 26. [Epub
ahead of print]
3. Saito, K., Dubreuil, V., Arai, Y., Wilsch-Bräuninger, M., Schwudke, D., Saher, G., Miyata, T.,
Breier, G., Thiele, C., Shevchenko, A., Nave, K.A., Huttner, W.B. (2009). Ablation of cholesterol
biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes
neuron apoptosis. Proc. Natl. Acad. Sci. U.S.A. 106: 8350-8355.
4. Labelle, M., Schnittler, H.J., Aust, D.E., Friedrich, K., Baretton, G., Vestweber, D., Breier, G.
(2008). Vascular endothelial cadherin promotes breast cancer progression via transforming growth
factor beta signaling. Cancer Res. 68, 1388–1397.
5. Heidenreich, R., Murayama, T., Silver, M., Essl, C., Asahara, T., Rocken, M., Breier, G. (2008):
Tracking adult neovascularization during ischemia and inflammation using Vegfr2-LacZ reporter
mice. J. Vasc. Res. 45, 437-444.
6. Diez, H., Fischer, A., Winkler, A., Hu, C.J., Hatzopoulos, A.K., Breier, G., Gessler, M. (2007).
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and
adoption of arterial cell fate. Exp. Cell Res. 313, 1-9.
7. Gille, J., Heidenreich, R., Pinter, A., Schmitz, J., Boehme, B., Hicklin, D.J., Henschler, R., Breier,
G. (2007). Simultaneous blockade of VEGFR-1 and VEGFR-2 activation is necessary to efficiently
inhibit experimental melanoma growth and metastasis formation. Int. J. Cancer 120, 1899-1908.
8. Li, X., Edholm, D., Lanner, F., Breier, G., Farnebo, F., Dimberg, A., Claesson-Welsh, L. (2007).
Lentiviral rescue of vascular endothelial growth factor receptor-2 expression in flk1-/- embryonic
stem cells shows early priming of endothelial precursors. Stem Cells 25, 2987-2995.
9. Breier, G., Licht, A.H., Nicolaus, A., Klotzsche, A., Wielockx, B., Kirsnerova, Z. (2007). HIF in
vascular development and tumour angiogenesis. Novartis Found Symp 283,126-133.
10. Licht, A.H., Muller-Holtkamp, F., Flamme, I., Breier, G. (2006). Inhibition of hypoxia-inducible
factor activity in endothelial cells disrupts embryonic cardiovascular development. Blood 107, 584-
590. An Inside Blood Analysis of this article (author: Greg Semenza) appeared at the front of the
same issue.
Stand: 29.03.2011