Immunotolerance in Regeneration Research topic(s) - Universitäts ...

Immunotolerance in Regeneration
Research topic(s):
•Molecular and cellular pathways governing the generation and function of Treg and Th17 cells
•Mechanisms of immune regulation by Foxp3 � and Foxp3 + Treg cells
•Molecular networks in immunity, tolerance and autoimmunity (including miRNAs)
•Antigen-specific Treg as gain-of-function targets in autoimmune diseases (autoimmune
diabetes / pancreatic beta-cell replacement, multiple sclerosis and rheumatoid arthritis)
•Role of Treg in homeostatic hematopoiesis and hematopoietic stem cell transplantation
•Neuro-immune crosstalk in health and disease
Group leader(s):
Karsten Kretschmer, PhD
Immunotolerance in Regeneration - CRTD / DFG-Center for Regenerative Therapies Dresden
c/o Institute of Physiological Chemistry, MTZ
TU Dresden
Fiedlerstr. 42
01307 Dresden, Germany
Tel.: +49 (0) 351-458-6442
Fax: +49 (0) 351-458-6319
E-mail: Karsten.Kretschmer@crt-dresden.de
Web page: http://www.crt-dresden.de/research/crtd-core-groups/kretschmer/
http://www.researcherid.com/rid/E-8174-2010
08/2007 – present Group leader, Research Group Immunotolerance in Regeneration,
CRTD / DFG-Center for Regenerative Therapies Dresden, Germany
07/2003 – 07/2007 Postdoctoral fellow, Laboratory of Lymphocyte Biology (H. von
Boehmer), Department of Pathology, Harvard Medical School; and
Department of Cancer Immunology & AIDS, Dana-Farber Cancer
Institute, Boston, USA
05/2001 – 09/2001 Research project ‘Gene expression profiling of B cell subpopulations’,
Basel Institute for Immunology (A. Rolink), Basel, Switzerland
05/1999 – 06/2003 Doctorate (‘summa cum laude’), Research Group Molecular Immunology
(S. Weiss), Department of Cell Biology and Immunology (J. Wehland),
Helmholtz Centre for Infection Research, Braunschweig, Germany
11/1997 – 01/1999 Diploma thesis, Research Group Molecular Immunology (S. Weiss),
Department of Cell Biology and Immunology (J. Wehland), Helmholtz
Centre for Infection Research, Braunschweig, Germany
10/1995 – 10/1996 Graduate courses in Immunology, Molecular Biology and Biochemistry,
Università degli Studi di Pavia, Pavia, Italy
10/1991 – 01/1999 Study of Biology at the Technische Universität Carolo-Wilhelmina zu
Braunschweig, Germany
Stand: 04.04.2011

Group members:
Marie Boernert Technician
Marcin Dembinski Predoc
Anna Gleinig Student
Mangesh Tulshidas Jaykar Predoc
Tina König Technician
Anita Kunert Predoc
Odette Leiter Student
Melanie Naumann Biomedical Service
Johannes Niebling Medical Student
Silvia Palme Assistant (Administration)
Cathleen Petzold Predoc
Julia Riewaldt Predoc
Sonja Schallenberg Postdoc
Pei-Yun Tsai Predoc
Memberships
•German Society of Immunology (DGfI)
•Deutsche Diabetes Gesellschaft (DDG)
•DGfI Study Group ‘Type I, II, and III immune responses’ (Speaker: Michael Lohoff)
•DGfI Study Group ‘Biology of B Lymphocytes’ (Speaker: Hans-Martin Jäck)
Referee Service
• Ad-hoc referee for The Journal of Immunology, The European Journal of Immunology, Journal
of Molecular Medicine, Nature Protocols, PNAS, Blood, The Journal of Experimental Medicine,
Diabetologia etc.
•Editorial Board Member of The Review of Diabetic Studies (RDS)
•Associate Editor of Frontiers in Immunological Tolerance
•Spanish Ministry of Science and Innovation (MICINN)
•National Health & Medical Research Council (NHMRC, Australia)
•Deutsche Forschungsgemeinschaft (DFG)
Internal collaborators:
•K. Anastassiadis (CRTD)
•A. Beyer (BIOTEC, Dresden)
•E. Bonifacio (CRTD)
•F. Buchholz (MPI-CBG Dresden)
•A. Garbe & R. Jessberger (Institute of Physiological Chemistry, Dresden)
•B. Hoflack (BIOTEC, Dresden)
•G. Kempermann (CRTD)
•F. Stewart (BIOTEC, Dresden)
•C. Waskow (CRTD)
•S. Speier (CRTD)
Participation in collaborative research projects (local, national, international):
Associated member SFB 655, BMBF - Competence Network Diabetes Mellitus, BMBF - Paul-
Langerhans Institute Dresden (PLID)
Stand: 04.04.2011

List of ten most important publications 2005–2011:
1. Stern, J.N.H.* † , Keskin, D.B.*, Kato, Z., Waldner, H., Schallenberg, S., Anderson, A., von Boehmer,
H., Kretschmer, K.* † , and Strominger J.L. † , Promoting tolerance to proteolipid protein-induced
experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc Natl Acad Sci U
S A. 2010 Oct 5;107(40):17280. Corresponding † and equally contributing first author*.
2. Schallenberg, S., Tsai, P.Y., Riewaldt J., and Kretschmer, K., Identification of an immediate Foxp3 �
precursor population to Foxp3 + regulatory T cells in peripheral lymphoid organs of nonmanipulated
mice. J Exp Med. 2010; 207(7):1393.
3. Petzold, C.*, Riewaldt, J.*, Koenig, T., Schallenberg, S, and Kretschmer, K., Dendritic cell targeted
pancreatic beta cell antigen leads to conversion of self-reactive CD4 + T cells into regulatory T cells
and immunotolerance in NOD mice. Rev Diabet Stud. 2010. 7:45. *These authors contributed
equally.
4. Feuerer, M., Hill, J., Kretschmer, K., von Boehmer, H., Mathis, D., and Benoist, C., Genomic
definition of multiple ex vivo Treg sub-phenotypes. Proc Natl Acad Sci U S A. 2010. 30; 107
(13):5919.
5. Nolting, J., Daniel, C., Stuelten, C., Li, P., Sucov, H., Kim, B.G., Letterio, J.J., Kretschmer, K., Kim,
H.J., von Boehmer, H., Retinoic acid can enhance conversion of naive into regulatory T cells
independently of secreted cytokines. J Exp Med. 2009. 28; 206(10):2131.
6. Duber S., Hafner M., Krey M., Lienenklaus S., Roy B., Hobeika E., Reth M., Buch T., Waisman A.,
Weiss S.*, and Kretschmer K.*, Induction of B cell development in adult mice reveals the
ability of bone marrow to produce B-1a cells. Blood. 2009. 114: 4960. *shared senior authorship.
7. Marson, A.*, Kretschmer, K.*, Frampton G.M., Jacobsen, E.S., Polansky, J.K., MacIsaac, K.D.,
Levine, S.S., Fraenkel, E., von Boehmer, H., and Young, R.A. Foxp3 occupancy and regulation of key
target genes during T-cell stimulation. Nature. 2007. 445(7130):931. *These authors contributed
equally.
8. Kretschmer, K., Apostolou, I., Jaeckel, E., Khazaie, K., and von Boehmer H., Making regulatory T
cells with defined antigen specificity: Role in autoimmunity and cancer. Review. Immunol. Rev. 2006.
212: 163.
9. Kretschmer, K., Heng, T.S.P., and von Boehmer, H., De novo production of antigen specific
suppressor cells in vivo. Nat. Protocols. 2006. 1(2):653.
10. Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M.C., and von Boehmer, H.,
Inducing and expanding regulatory T cells by foreign antigen. Nat. Immunol. 2005. 6: 1219.
Stand: 04.04.2011