Experimental Hematology Research topic(s) - Universitäts ...

Experimental Hematology
Research topic(s):
1. Hematopoietic Stem Cell Migration
2. Gene Therapy for Patients with Chronic Granulomatous Disease
Group leader(s):
PD Dr. med. Sebastian Brenner
Department of Pediatrics
University Clinic Carl Gustav Carus
Technische Universität Dresden
Fetscherstraße 74
01307 Dresden
Ph: +49-351-458 6833
Fax: +49-351 458 6333
E-mail: Sebastian.Brenner@uniklinikum-dresden.de
Education:
1990 Abitur, Gymnasium Tegernsee, Germany
1990-1997 Medical School: University of Saarland, Homburg/Saar; University
College Dublin, Ireland; Free University Berlin and Humboldt University
to Berlin
1999 Approbation
1999 Dr. med., Humboldt University to Berlin, Germany
2006 Board certified Pediatrician
2008 Board certified Neonatologist
2010 Habilitation (PhD)
Training:
1997-1999 Arzt im Praktikum (Internship), Department of Pediatrics, University
Clinic Dresden (UCD)
1999 Resident, Department of Pediatrics, University Clinic Dresden
1999-2003 Postdoctoral Fellow at the Laboratory of Host Defenses, NIH, USA
2003-2006 Resident, Department of Pediatrics, University Clinic Dresden
since 2008 Senior Physician, Department of Pediatrics, University Clinic Dresden
Clinical Experience:
Experience in general pediatrics, neonatology and pediatric intensive care medicine
Professional Appointment:
Senior Physician at the Department of Pediatrics, University Clinic Dresden
Publications: 27 scientific publications in peer reviewed journals, one patent
Funding: Extrabudgetary funding by DFG, Deutsche Krebshilfe, BMBF
Journals: Reviewer for Blood, Stem Cells, Tissue Engineering and others
Editorial Advisory Board Member of Current Stem Cell Research &
Therapy and The Open Tissue Engineering & Regenerative Medicine
Journal
Grant review: DFG, CGD Trust, Swiss National Science Foundation
Societies: Member of Deutsche Gesellschaft für Kinder- und Jugendmedizin,
Gesellschaft für Neonatology und Pädiatrische Intensivmedizin,
European Society of Intensive Care Medicine
Group members:
Scientists: Dr. Sebastian Thieme, Dr. Magdalena Laugsch, Dr. Cornelia Richter,
Dr. Tobias Gyarfas
Technician: Katrin Navratiel

Internal collaborators:
Gerhard Ehninger, Martin Bornhäuser, Department of Internal Medicine I
Dirk Lindemann, Institute of Virology
Dennis Corbeil, Francis Stewart and Konstantinos Anastassiadis, Biotec Center TU Dresden
Frank Buchholz, CBG-MPI Dresden
External collaborators:
Harry L. Malech, LHD, NIAID, NIH, Bethesda, USA
Participation in collaborative research projects (local, national, international):
DFG SFB 655
DFG Center for Regenerative Therapies (CRTD)
List of ten most important publications 2005-2010:
1. Jacobi A, Thieme S, Lehmann R, Ugarte F, Malech HL, Koch S, Thiede C, Müller K, Bornhäuser
M, Ryser M, Brenner S. (2010). Impact of CXCR4 inhibition on FLT3-ITD-positive human AML
blasts. Exp Hematol. Mar;38(3):180-90.
2. Ugarte F, Ryser M, Thieme S, Fierro FA, Navratiel K, Bornhäuser M, Brenner S. (2009). Notch
signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human
bone marrow stromal cells. Exp Hematol. Jul;37(7):867-875.
3. Ryser MF, Thieme S, Lehmann R, Bornhäuser M, Brenner S. (2009). Serum albumin strongly
influences SDF-1 dependent migration. Int J Hematol. Apr;89(3):269-75.
4. Fierro FA, Brenner S, Oelschlaegel U, Jacobi A, Knoth H, Ehninger G, Illmer T, Bornhäuser M.
(2009) Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid
leukemia. Leukemia. Feb;23(2):393-6.
5. Moreno-Carranza B, Gentsch M, Stein S, Schambach A, Santilli G, Rudolf E, Ryser MF, Haria S,
Thrasher AJ, Baum C, Brenner S, Grez M. (2009). Transgene optimization significantly improves
SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD
cells. Gene Ther. Jan16(1):111-8.
6. Ryser MF, Ugarte F, Gentsch M, Lehmann R, Bornhäuser M, Brenner S. (2008). S1P1
overexpression stimulates S1P dependent chemotaxis of human hematopoietic stem cells but
strongly inhibits SDF-1/CXCR4 dependent migration and in vivo homing. Mol Immunol.
Nov;46,166-71.
7. Ryser MF, Ugarte F, Thieme S, Gentsch M, Bornhäuser M, Roesen-Wolff A, Brenner S. (2008).
mRNA transfection of a CXCR4-GFP fusion protein - generated by a simple three step PCR
protocol - results in efficient migration of primary mesenchymal stem cells. Tissue Eng Part C
Methods. Sep;14,179-84.
8. Brenner S, Ryser MF, Whiting-Theobald NL, Gentsch M, Linton GF, Malech HL. (2007). The late
dividing population of gamma-retroviral vector transduced human mobilized peripheral blood
progenitor cells contributes most to gene-marked cell engraftment in nonobese diabetic/severe
combined immunodeficient mice. Stem Cells. Jul;25(7):1807-13.
9. Brenner S, Ryser MF, Choi U, Whiting-Theobald N, Kuhlisch E, Linton G, Kang E, Lehmann R,
Rosen-Wolff A, Rudikoff AG, Farese AM, MacVittie TJ, Roesler J, Horwitz ME, Malech HL.
(2006). Polyclonal long-term MFGS-gp91phox marking in rhesus macaques after nonmyeloablative
transplantation with transduced autologous peripheral blood progenitor cells. Mol
Ther. Aug;14(2):202-11.
10. Ueda T, Brenner S, Malech HL, Langemeijer SM, Perl S, Kirby M, Phang OA, Krouse AE,
Donahue RE, Kang EM, Tisdale JF. (2005). Cloning and functional analysis of the rhesus
macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem
cell progeny in vivo. J Biol Chem. Jan 14;280(2):991-8.