Curriculum Vitae - Universitäts KrebsCentrum Dresden

Molecular Hematology
Research topic(s):
1. Molecular abnormalities in acute myeloid leukaemia onset and progression
2. Molecular diagnostics for guidance of treatment in leukaemia and post allogeneic
transplantation
3. Mechanisms of cell migration and stem cell homing
Group leader(s):
Prof. Dr. med. Christian Thiede
Department of Internal Medicine I
University Hospital Carl Gustav Carus
Fetscherstraße 74
01307 Dresden
Ph.: +49-351-458 4680
Fax: +49-351-458 5362
E-mail: Christian.Thiede@uniklinikum-dresden.de
Education: 1986-1993 Free University, Berlin, Germany
1993 Medical Exams, Berlin, Germany
Training:
Clinical Experience:
Professional Appointments:
1994 MD Thesis (P53-mutations in colorectal cancer, Hematology/Oncology,
Prof. Huhn, Free University, Berlin)
1993-96 Postdoctoral fellow with Prof. Andreas Neubauer, Humboldt-University,
Berlin, Germany
1996-1999 Postdoctoral fellow with Prof. Neubauer, Dept. of Internal medicine I
Medical Faculty Carl Gustav Carus, Dresden University of Technology,
1999-present Group leader, Dept. of Internal medicine I, Medical Faculty Carl Gustav
Carus, Dresden University of Technology,
2003 Venia legendi (Experimental Internal Medicine), University of Basel
Medical Faculty Carl Gustav Carus, Dresden University of Technology,
Germany
2006 W2-Professor for Molecular Hematology
Funding: DFG, BMBF, Krebshilfe
Award: Novartis Post Graduate Award for Cinical Research, Young
investigators award EHPSG 1996
Journals: Blood, Oncogene, Leukemia, Clin Cancer Research,+20 others
Grant review: MeDDrive,
Societies: DGHO, AACR, ASH,
Group members:
Post Docs Sylvia Herold
PhD students: Claudia Ortlepp, Sylvia Kaulfuss
MD students: Franziska Taube, Katharina Gerstenberger, Romy Eichner
Internal collaborators with academic status:
Martin Bornhäuser, Stephan Miehlke
Rainer Ordemann, Markus Schaich, Thomas Illmer, Department of Internal Medicine I
Meinolf Suttorp, Sebastian Brenner, Department of Pediatrics

External collaborators with affiliation:
H. Serve, Johann-Wolfgang Goethe Universität Frankfurt
B. Falini, University Perugia
C. Bloomfield, Ohio State University, Columbus Ohio, USA
Participation in collaborative research projects (local, national, international):
SFB 655 From Cells to Tissues
NGFNplus
European Leukemia Network (ELN)
Kompetenznetzwerk Akute und Chronische Leukämien
List of ten most important publications 2004-2009:
1. Oelschlaegel,U., Mohr,B., Schaich,M., Schakel,U., Kroschinsky,F., Illmer,T.,
Ehninger,G., and Thiede,C. (2009). HLA-DRneg patients without acute promyelocytic
leukemia show distinct immunophenotypic, genetic, molecular, and cytomorphologic
characteristics compared to acute promyelocytic leukemia. Cytometry B Clin. Cytom. 76, 321-
327.
2. Hollink,I.H., Zwaan,C.M., Zimmermann,M., Arentsen-Peters,T.C., Pieters,R., Cloos,J.,
Kaspers,G.J., de Graaf,S.S., Harbott,J., Creutzig,U., Reinhardt,D., van den Heuvel-Eibrink
MM, and Thiede,C. (2009). Favorable prognostic impact of NPM1 gene mutations in childhood
acute myeloid leukemia, with emphasis on cytogenetically normal AML. Leukemia 23, 262-
270.
3. Koch,S., Jacobi,A., Ryser,M., Ehninger,G., and Thiede,C. (2008). Abnormal
localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in
leukemogenesis. Cells Tissues. Organs 188, 225-235.
4. Bornhauser,M., Illmer,T., Schaich,M., Soucek,S., Ehninger,G., and Thiede,C. (2007).
Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML. Blood 109, 2264-
2265.
5. Thiede,C., Creutzig,E., Reinhardt,D., Ehninger,G., and Creutzig,U. (2007). Different
types of NPM1 mutations in children and adults: evidence for an effect of patient age on the
prevalence of the TCTG-tandem duplication in NPM1-exon 12. Leukemia 21, 366-367.
6. Thiede,C., Koch,S., Creutzig,E., Steudel,C., Illmer,T., Schaich,M., and Ehninger,G.
(2006). Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with
acute myeloid leukemia (AML). Blood 107, 4011-4020.
7. Baldus,C.D., Thiede,C., Soucek,S., Bloomfield,C.D., Thiel,E., and Ehninger,G.
(2006). BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid
leukemia patients with normal cytogenetics: prognostic implications. J. Clin. Oncol. 24, 790-
797.
8. Wundisch,T., Thiede,C., Morgner,A., Dempfle,A., Gunther,A., Liu,H., Ye,H., Du,M.Q.,
Kim,T.D., Bayerdorffer,E., Stolte,M., and Neubauer,A. (2005). Long-term follow-up of gastric
MALT lymphoma after Helicobacter pylori eradication. J. Clin. Oncol. 23, 8018-8024.
9. Grundler,R., Miething,C., Thiede,C., Peschel,C., and Duyster,J. (2005). FLT3-ITD
and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow
transplantation model. Blood 105, 4792-4799.
10. Thiede,C., Bornhauser,M., and Ehninger,G. (2004). Evaluation of STR informativity
or chimerism testing--comparative analysis of 27 STR systems in 203 matched related donor
recipient pairs. Leukemia 18, 248-254.