accepted manuscript

Figure Legends
Table 1.
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PD-associated loci and genes with conclusive evidence
Figure 1. Parkin, PINK1 and mitochondrial dynamics. A. Key players of the
mitochondrial fusion and fission machinery. For reviews on mitochondrial dynamics
see [319-322] B. Transient downregulation of parkin or PINK1 by RNA interference
induces alterations in mitochondrial morphology in human SH-SY5Y cells. Control
siRNA-transfected cells show a network of tubular mitochondria. Parkin or PINK1
loss of function results in mitochondrial fragmentation, which also occurs in Mfn2-
deficient cells due to an relative increase in mitochondrial fission.
Figure 2. Mitochondrial alterations associated with PD.
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