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ACCEPTED MANUSCRIPT the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion, The Journal of biological chemistry 277 (2002) 48984-48992. [277] J. Xu, S.Y. Kao, F.J. Lee, W. Song, L.W. Jin, B.A. Yankner, Dopamine- dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease, Nature medicine 8 (2002) 600-606. [278] H.A. Lashuel, D. Hartley, B.M. Petre, T. Walz, P.T. Lansbury, Jr., Neurodegenerative disease: amyloid pores from pathogenic mutations, Nature 418 (2002) 291. [279] M.J. Volles, S.J. Lee, J.C. Rochet, M.D. Shtilerman, T.T. Ding, J.C. Kessler, P.T. Lansbury, Jr., Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease, Biochemistry 40 (2001) 7812-7819. [280] W.W. Li, R. Yang, J.C. Guo, H.M. Ren, X.L. Zha, J.S. Cheng, D.F. Cai, Localization of alpha-synuclein to mitochondria within midbrain of mice, Neuroreport 18 (2007) 1543-1546. [281] K. Nakamura, V.M. Nemani, E.K. Wallender, K. Kaehlcke, M. Ott, R.H. ACCEPTED MANUSCRIPT Edwards, Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria, J Neurosci 28 (2008) 12305-12317. [282] L. Zhang, C. Zhang, Y. Zhu, Q. Cai, P. Chan, K. Ueda, S. Yu, H. Yang, Semi- quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody, Brain research 1244 (2008) 40-52. [283] S. Shavali, H.M. Brown-Borg, M. Ebadi, J. Porter, Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells, 79
ACCEPTED MANUSCRIPT Neuroscience letters 439 (2008) 125-128. [284] N.B. Cole, D. Dieuliis, P. Leo, D.C. Mitchell, R.L. Nussbaum, Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification, Experimental cell research 314 (2008) 2076-2089. [285] M.S. Parihar, A. Parihar, M. Fujita, M. Hashimoto, P. Ghafourifar, Mitochondrial association of alpha-synuclein causes oxidative stress, Cell Mol Life Sci 65 (2008) 1272-1284. [286] L. Devi, V. Raghavendran, B.M. Prabhu, N.G. Avadhani, H.K. Anandatheerthavarada, Mitochondrial import and accumulation of alpha- synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain, The Journal of biological chemistry 283 (2008) 9089- 9100. [287] L.J. Hsu, Y. Sagara, A. Arroyo, E. Rockenstein, A. Sisk, M. Mallory, J. Wong, T. Takenouchi, M. Hashimoto, E. Masliah, alpha-synuclein promotes mitochondrial deficit and oxidative stress, The American journal of pathology 157 (2000) 401-410. [288] H.F. Poon, M. Frasier, N. Shreve, V. Calabrese, B. Wolozin, D.A. Butterfield, ACCEPTED MANUSCRIPT Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease, Neurobiology of disease 18 (2005) 492-498. [289] M. Orth, S.J. Tabrizi, Models of Parkinson's disease, Mov Disord 18 (2003) 729-737. [290] D.D. Song, C.W. Shults, A. Sisk, E. Rockenstein, E. Masliah, Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP, Experimental neurology 186 (2004) 158- 80
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