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ACCEPTED MANUSCRIPT [104] M.J. Farrer, Genetics of Parkinson disease: paradigm shifts and future prospects, Nat Rev Genet 7 (2006) 306-318. [105] S. Lesage, A. Brice, Parkinson's disease: from monogenic forms to genetic susceptibility factors, Human molecular genetics 18 (2009) R48-59. [106] T. Gasser, Mendelian forms of Parkinson's disease, Biochimica et biophysica acta 1792 (2009) 587-596. [107] A. Ramirez, A. Heimbach, J. Grundemann, B. Stiller, D. Hampshire, L.P. Cid, I. Goebel, A.F. Mubaidin, A.L. Wriekat, J. Roeper, A. Al-Din, A.M. Hillmer, M. Karsak, B. Liss, C.G. Woods, M.I. Behrens, C. Kubisch, Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase, Nature genetics 38 (2006) 1184-1191. [108] A. Di Fonzo, H.F. Chien, M. Socal, S. Giraudo, C. Tassorelli, G. Iliceto, G. Fabbrini, R. Marconi, E. Fincati, G. Abbruzzese, P. Marini, F. Squitieri, M.W. Horstink, P. Montagna, A.D. Libera, F. Stocchi, S. Goldwurm, J.J. Ferreira, G. Meco, E. Martignoni, L. Lopiano, L.B. Jardim, B.A. Oostra, E.R. Barbosa, V. Bonifati, ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease, Neurology 68 (2007) 1557-1562. ACCEPTED MANUSCRIPT [109] A. Abeliovich, M. Flint Beal, Parkinsonism genes: culprits and clues, Journal of neurochemistry 99 (2006) 1062-1072. [110] R.E. Burke, Programmed cell death and new discoveries in the genetics of parkinsonism, Journal of neurochemistry 104 (2008) 875-890. [111] J.C. Fitzgerald, H. Plun-Favreau, Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway?, The FEBS journal 275 (2008) 5758-5766. [112] A. Wood-Kaczmar, S. Gandhi, N.W. Wood, Understanding the molecular 53
ACCEPTED MANUSCRIPT causes of Parkinson's disease, Trends Mol Med 12 (2006) 521-528. [113] D.J. Moore, A.B. West, V.L. Dawson, T.M. Dawson, Molecular Pathophysiology of Parkinson's Disease, Annu Rev Neurosci 28 (2005) 57-87. [114] M.R. Cookson, The biochemistry of Parkinson's disease, Annual review of biochemistry 74 (2005) 29-52. [115] E.M. Valente, P.M. Abou-Sleiman, V. Caputo, M.M. Muqit, K. Harvey, S. Gispert, Z. Ali, D. Del Turco, A.R. Bentivoglio, D.G. Healy, A. Albanese, R. Nussbaum, R. Gonzalez-Maldonado, T. Deller, S. Salvi, P. Cortelli, W.P. Gilks, D.S. Latchman, R.J. Harvey, B. Dallapiccola, G. Auburger, N.W. Wood, Hereditary early-onset Parkinson's disease caused by mutations in PINK1, Science (New York, N.Y 304 (2004) 1158-1160. [116] R.D. Mills, C.H. Sim, S.S. Mok, T.D. Mulhern, J.G. Culvenor, H.C. Cheng, Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1), Journal of neurochemistry 105 (2008) 18-33. [117] A. Petit, T. Kawarai, E. Paitel, N. Sanjo, M. Maj, M. Scheid, F. Chen, Y. Gu, H. Hasegawa, S. Salehi-Rad, L. Wang, E. Rogaeva, P. Fraser, B. Robinson, P. St George-Hyslop, A. Tandon, Wild-type PINK1 prevents basal and induced ACCEPTED MANUSCRIPT neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations, The Journal of biological chemistry 280 (2005) 34025-34032. [118] H. Deng, J. Jankovic, Y. Guo, W. Xie, W. Le, Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y, Biochemical and biophysical research communications 337 (2005) 1133-1138. [119] M.E. Haque, K.J. Thomas, C. D'Souza, S. Callaghan, T. Kitada, R.S. Slack, P. Fraser, M.R. Cookson, A. Tandon, D.S. Park, Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP, Proceedings of the 54
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