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ACCEPTED MANUSCRIPT [185] C. Wang, J.M. Tan, M.W. Ho, N. Zaiden, S.H. Wong, C.L. Chew, P.W. Eng, T.M. Lim, T.M. Dawson, K.L. Lim, Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease- linked point mutations, Journal of neurochemistry 93 (2005) 422-431. [186] C. Wang, H.S. Ko, B. Thomas, F. Tsang, K.C. Chew, S.P. Tay, M.W. Ho, T.M. Lim, T.W. Soong, O. Pletnikova, J. Troncoso, V.L. Dawson, T.M. Dawson, K.L. Lim, Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function, Human molecular genetics 14 (2005) 3885-3897. [187] E.S. Wong, J.M. Tan, C. Wang, Z. Zhang, S.P. Tay, N. Zaiden, H.S. Ko, V.L. Dawson, T.M. Dawson, K.L. Lim, Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations, The Journal of biological chemistry 282 (2007) 12310-12318. [188] M.J. LaVoie, B.L. Ostaszewski, A. Weihofen, M.G. Schlossmacher, D.J. Selkoe, Dopamine covalently modifies and functionally inactivates parkin, Nature medicine 11 (2005) 1214-1221. [189] D. Yao, Z. Gu, T. Nakamura, Z.Q. Shi, Y. Ma, B. Gaston, L.A. Palmer, E.M. ACCEPTED MANUSCRIPT Rockenstein, Z. Zhang, E. Masliah, T. Uehara, S.A. Lipton, Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity, Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 10810-10814. Epub 12004 Jul 10813. [190] K.K. Chung, B. Thomas, X. Li, O. Pletnikova, J.C. Troncoso, L. Marsh, V.L. Dawson, T.M. Dawson, S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function, Science (New York, N.Y 304 65
ACCEPTED MANUSCRIPT (2004) 1328-1331. Epub 2004 Apr 1322. [191] F. Darios, O. Corti, C.B. Lucking, C. Hampe, M.P. Muriel, N. Abbas, W.J. Gu, E.C. Hirsch, T. Rooney, M. Ruberg, A. Brice, Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death, Human molecular genetics 12 (2003) 517-526. [192] A.K. Berger, G.P. Cortese, K.D. Amodeo, A. Weihofen, A.G. Letai, M.J. Lavoie, Parkin Selectively Alters the Intrinsic Threshold for Mitochondrial Cytochrome C Release, Human molecular genetics (2009). [193] C.C. Stichel, M. Augustin, K. Kuhn, X.R. Zhu, P. Engels, C. Ullmer, H. Lubbert, Parkin expression in the adult mouse brain, The European journal of neuroscience 12 (2000) 4181-4194. [194] Y. Kuroda, T. Mitsui, M. Kunishige, M. Shono, M. Akaike, H. Azuma, T. Matsumoto, Parkin enhances mitochondrial biogenesis in proliferating cells, Human molecular genetics 15 (2006) 883-895. [195] O. Rothfuss, H. Fischer, T. Hasegawa, M. Maisel, P. Leitner, F. Miesel, M. Sharma, A. Bornemann, D. Berg, T. Gasser, N. Patenge, Parkin protects Mitochondrial Genome Integrity and supports Mitochondrial DNA Repair, ACCEPTED MANUSCRIPT Human molecular genetics (2009). [196] M.J. Casarejos, J. Menendez, R.M. Solano, J.A. Rodriguez-Navarro, J. Garcia de Yebenes, M.A. Mena, Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline, Journal of neurochemistry 97 (2006) 934-946. [197] J.C. Paterna, A. Leng, E. Weber, J. Feldon, H. Bueler, DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice, Mol Ther 15 (2007) 698-704. 66
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Abstract ACCEPTED MANUSCRIPT Mitoch
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ACCEPTED MANUSCRIPT function mechan
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ACCEPTED MANUSCRIPT high lipophilic
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ACCEPTED MANUSCRIPT transfer from N
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ACCEPTED MANUSCRIPT force (ΔpH and
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ACCEPTED MANUSCRIPT about 1500 diff
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Page 39 and 40: Acknowledgements ACCEPTED MANUSCRIP
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Page 47 and 48: ACCEPTED MANUSCRIPT [47] B. Janetzk
Page 49 and 50: 486-517. ACCEPTED MANUSCRIPT [63] B
Page 51 and 52: ACCEPTED MANUSCRIPT Parkinson's dis
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Page 57 and 58: ACCEPTED MANUSCRIPT [125] A. Grunew
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