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ACCEPTED MANUSCRIPT [40] A. Hald, J. Lotharius, Oxidative stress and inflammation in Parkinson's disease: is there a causal link?, Experimental neurology 193 (2005) 279-290. [41] A. Hartmann, S. Hunot, P.P. Michel, M.P. Muriel, S. Vyas, B.A. Faucheux, A. Mouatt-Prigent, H. Turmel, A. Srinivasan, M. Ruberg, G.I. Evan, Y. Agid, E.C. Hirsch, Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease, Proceedings of the National Academy of Sciences of the United States of America 97 (2000) 2875-2880. [42] A. Hartmann, J.D. Troadec, S. Hunot, K. Kikly, B.A. Faucheux, A. Mouatt- Prigent, M. Ruberg, Y. Agid, E.C. Hirsch, Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis, J Neurosci 21 (2001) 2247-2255. [43] A. Hartmann, P.P. Michel, J.D. Troadec, A. Mouatt-Prigent, B.A. Faucheux, M. Ruberg, Y. Agid, E.C. Hirsch, Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?, Journal of neurochemistry 76 (2001) 1785-1793. [44] A.H. Schapira, J.M. Cooper, D. Dexter, P. Jenner, J.B. Clark, C.D. Marsden, ACCEPTED MANUSCRIPT Mitochondrial complex I deficiency in Parkinson's disease, Lancet 1 (1989) 1269. [45] A.H. Schapira, J.M. Cooper, D. Dexter, J.B. Clark, P. Jenner, C.D. Marsden, Mitochondrial complex I deficiency in Parkinson's disease, Journal of neurochemistry 54 (1990) 823-827. [46] V.M. Mann, J.M. Cooper, S.E. Daniel, K. Srai, P. Jenner, C.D. Marsden, A.H. Schapira, Complex I, iron, and ferritin in Parkinson's disease substantia nigra, Annals of neurology 36 (1994) 876-881. 45
ACCEPTED MANUSCRIPT [47] B. Janetzky, S. Hauck, M.B. Youdim, P. Riederer, K. Jellinger, F. Pantucek, R. Zochling, K.W. Boissl, H. Reichmann, Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease, Neuroscience letters 169 (1994) 126-128. [48] W.D. Parker, Jr., S.J. Boyson, J.K. Parks, Abnormalities of the electron transport chain in idiopathic Parkinson's disease, Annals of neurology 26 (1989) 719-723. [49] D. Krige, M.T. Carroll, J.M. Cooper, C.D. Marsden, A.H. Schapira, Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group, Annals of neurology 32 (1992) 782-788. [50] R.H. Haas, F. Nasirian, K. Nakano, D. Ward, M. Pay, R. Hill, C.W. Shults, Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease, Annals of neurology 37 (1995) 714-722. [51] R. Benecke, P. Strumper, H. Weiss, Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes, Brain 116 ( Pt 6) (1993) 1451-1463. [52] L.A. Bindoff, M. Birch-Machin, N.E. Cartlidge, W.D. Parker, Jr., D.M. ACCEPTED MANUSCRIPT Turnbull, Mitochondrial function in Parkinson's disease, Lancet 2 (1989) 49. [53] V.M. Mann, J.M. Cooper, D. Krige, S.E. Daniel, A.H. Schapira, C.D. Marsden, Brain, skeletal muscle and platelet homogenate mitochondrial function in Parkinson's disease, Brain 115 ( Pt 2) (1992) 333-342. [54] D.J. Taylor, D. Krige, P.R. Barnes, G.J. Kemp, M.T. Carroll, V.M. Mann, J.M. Cooper, C.D. Marsden, A.H. Schapira, A 31P magnetic resonance spectroscopy study of mitochondrial function in skeletal muscle of patients with Parkinson's disease, Journal of the neurological sciences 125 (1994) 77- 46
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