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ACCEPTED MANUSCRIPT Annual review of biochemistry 76 (2007) 723-749. [90] S. Dimauro, G. Davidzon, Mitochondrial DNA and disease, Annals of medicine 37 (2005) 222-232. [91] R. Rossignol, B. Faustin, C. Rocher, M. Malgat, J.P. Mazat, T. Letellier, Mitochondrial threshold effects, The Biochemical journal 370 (2003) 751-762. [92] A.H. Schapira, Mitochondrial disease, Lancet 368 (2006) 70-82. [93] Y. Kraytsberg, E. Kudryavtseva, A.C. McKee, C. Geula, N.W. Kowall, K. Khrapko, Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons, Nature genetics 38 (2006) 518-520. [94] A. Bender, K.J. Krishnan, C.M. Morris, G.A. Taylor, A.K. Reeve, R.H. Perry, E. Jaros, J.S. Hersheson, J. Betts, T. Klopstock, R.W. Taylor, D.M. Turnbull, High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease, Nature genetics 38 (2006) 515-517. [95] A.K. Reeve, K.J. Krishnan, J.L. Elson, C.M. Morris, A. Bender, R.N. Lightowlers, D.M. Turnbull, Nature of mitochondrial DNA deletions in substantia nigra neurons, American journal of human genetics 82 (2008) 228- 235. ACCEPTED MANUSCRIPT [96] P. Luoma, A. Melberg, J.O. Rinne, J.A. Kaukonen, N.N. Nupponen, R.M. Chalmers, A. Oldfors, I. Rautakorpi, L. Peltonen, K. Majamaa, H. Somer, A. Suomalainen, Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study, Lancet 364 (2004) 875-882. [97] P.T. Luoma, J. Eerola, S. Ahola, A.H. Hakonen, O. Hellstrom, K.T. Kivisto, P.J. Tienari, A. Suomalainen, Mitochondrial DNA polymerase gamma 51
ACCEPTED MANUSCRIPT variants in idiopathic sporadic Parkinson disease, Neurology 69 (2007) 1152- 1159. [98] M.I. Ekstrand, M. Terzioglu, D. Galter, S. Zhu, C. Hofstetter, E. Lindqvist, S. Thams, A. Bergstrand, F.S. Hansson, A. Trifunovic, B. Hoffer, S. Cullheim, A.H. Mohammed, L. Olson, N.G. Larsson, Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons, Proceedings of the National Academy of Sciences of the United States of America 104 (2007) 1325-1330. [99] R.H. Swerdlow, J.K. Parks, S.W. Miller, J.B. Tuttle, P.A. Trimmer, J.P. Sheehan, J.P. Bennett, Jr., R.E. Davis, W.D. Parker, Jr., Origin and functional consequences of the complex I defect in Parkinson's disease, Annals of neurology 40 (1996) 663-671. [100] S.W. Miller, P.A. Trimmer, W.D. Parker, Jr., R.E. Davis, Creation and characterization of mitochondrial DNA-depleted cell lines with "neuronal- like" properties, Journal of neurochemistry 67 (1996) 1897-1907. [101] M. Gu, J.M. Cooper, J.W. Taanman, A.H. Schapira, Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease, Annals of ACCEPTED MANUSCRIPT neurology 44 (1998) 177-186. [102] Y. Aomi, C.S. Chen, K. Nakada, S. Ito, K. Isobe, H. Murakami, S.Y. Kuno, M. Tawata, R. Matsuoka, H. Mizusawa, J.I. Hayashi, Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function, Biochemical and biophysical research communications 280 (2001) 265-273. [103] V. Bonifati, Genetics of parkinsonism, Parkinsonism & related disorders 13 Suppl 3 (2007) S233-241. 52
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