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ACCEPTED MANUSCRIPT Downward, Neuroprotective role of the Reaper-related serine protease HtrA2/ Omi revealed by targeted deletion in mice, Molecular and cellular biology 24 (2004) 9848-9862. [144] K.M. Strauss, L.M. Martins, H. Plun-Favreau, F.P. Marx, S. Kautzmann, D. Berg, T. Gasser, Z. Wszolek, T. Muller, A. Bornemann, H. Wolburg, J. Downward, O. Riess, J.B. Schulz, R. Kruger, Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease, Human molecular genetics 14 (2005) 2099-2111. [145] V. Bogaerts, K. Nuytemans, J. Reumers, P. Pals, S. Engelborghs, B. Pickut, E. Corsmit, K. Peeters, J. Schymkowitz, P.P. De Deyn, P. Cras, F. Rousseau, J. Theuns, C. Van Broeckhoven, Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease, Human mutation 29 (2008) 832-840. [146] O.A. Ross, A.I. Soto, C. Vilarino-Guell, M.G. Heckman, N.N. Diehl, M.M. Hulihan, J.O. Aasly, S. Sando, J.M. Gibson, T. Lynch, A. Krygowska-Wajs, G. Opala, M. Barcikowska, K. Czyzewski, R.J. Uitti, Z.K. Wszolek, M.J. Farrer, Genetic variation of Omi/HtrA2 and Parkinson's disease, Parkinsonism ACCEPTED MANUSCRIPT & related disorders 14 (2008) 539-543. [147] J. Simon-Sanchez, A.B. Singleton, Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls, Human molecular genetics 17 (2008) 1988-1993. [148] W. Lin, U.J. Kang, Characterization of PINK1 processing, stability, and subcellular localization, Journal of neurochemistry 106 (2008) 464-474. [149] A. Weihofen, B. Ostaszewski, Y. Minami, D.J. Selkoe, Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the 59
ACCEPTED MANUSCRIPT maturation or subcellular distribution of Pink1, Human molecular genetics 17 (2008) 602-616. [150] C. Zhou, Y. Huang, Y. Shao, J. May, D. Prou, C. Perier, W. Dauer, E.A. Schon, S. Przedborski, The kinase domain of mitochondrial PINK1 faces the cytoplasm, Proceedings of the National Academy of Sciences of the United States of America 105 (2008) 12022-12027. [151] L. Silvestri, V. Caputo, E. Bellacchio, L. Atorino, B. Dallapiccola, E.M. Valente, G. Casari, Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism, Human molecular genetics 14 (2005) 3477-3492. [152] S. Gandhi, M.M. Muqit, L. Stanyer, D.G. Healy, P.M. Abou-Sleiman, I. Hargreaves, S. Heales, M. Ganguly, L. Parsons, A.J. Lees, D.S. Latchman, J.L. Holton, N.W. Wood, T. Revesz, PINK1 protein in normal human brain and Parkinson's disease, Brain 129 (2006) 1720-1731. [153] M.M. Muqit, P.M. Abou-Sleiman, A.T. Saurin, K. Harvey, S. Gandhi, E. Deas, S. Eaton, M.D. Payne Smith, K. Venner, A. Matilla, D.G. Healy, W.P. Gilks, A.J. Lees, J. Holton, T. Revesz, P.J. Parker, R.J. Harvey, N.W. Wood, ACCEPTED MANUSCRIPT D.S. Latchman, Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress, Journal of neurochemistry 98 (2006) 156- 169. [154] A. Beilina, M. Van Der Brug, R. Ahmad, S. Kesavapany, D.W. Miller, G.A. Petsko, M.R. Cookson, Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability, Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 5703-5708. 60
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ÔØ ÅÒÙ× ÖÔØ Mitochondrial
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Abstract ACCEPTED MANUSCRIPT Mitoch
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ACCEPTED MANUSCRIPT function mechan
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ACCEPTED MANUSCRIPT high lipophilic
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Page 41 and 42: References ACCEPTED MANUSCRIPT [1]
Page 43 and 44: ACCEPTED MANUSCRIPT Sciences of the
Page 45 and 46: ACCEPTED MANUSCRIPT biological chem
Page 47 and 48: ACCEPTED MANUSCRIPT [47] B. Janetzk
Page 49 and 50: 486-517. ACCEPTED MANUSCRIPT [63] B
Page 51 and 52: ACCEPTED MANUSCRIPT Parkinson's dis
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Page 55 and 56: ACCEPTED MANUSCRIPT causes of Parki
Page 57 and 58: ACCEPTED MANUSCRIPT [125] A. Grunew
Page 59: ACCEPTED MANUSCRIPT [136] G.B. John
Page 63 and 64: ACCEPTED MANUSCRIPT [163] C. Hampe,
Page 65 and 66: 114-122. ACCEPTED MANUSCRIPT [179]
Page 67 and 68: ACCEPTED MANUSCRIPT (2004) 1328-133
Page 69 and 70: ACCEPTED MANUSCRIPT Dalkara, N. Oze
Page 71 and 72: ACCEPTED MANUSCRIPT [217] H. Deng,
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Page 75 and 76: 35 (2001) 301-310. ACCEPTED MANUSCR
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Page 83 and 84: ACCEPTED MANUSCRIPT Ferrante, N.W.
Page 85 and 86: ACCEPTED MANUSCRIPT Meitinger, W. K
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