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(2009) 384-392. ACCEPTED MANUSCRIPT [73] R. Fato, C. Bergamini, S. Leoni, P. Strocchi, G. Lenaz, Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration, Neurochemical research 33 (2008) 2487-2501. [74] M. Valko, D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur, J. Telser, Free radicals and antioxidants in normal physiological functions and human disease, The international journal of biochemistry & cell biology 39 (2007) 44-84. [75] M. Giorgio, M. Trinei, E. Migliaccio, P.G. Pelicci, Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?, Nat Rev Mol Cell Biol 8 (2007) 722-728. [76] I.B. Afanas'ev, Signaling functions of free radicals superoxide & nitric oxide under physiological & pathological conditions, Molecular biotechnology 37 (2007) 2-4. [77] T.J. Schulz, K. Zarse, A. Voigt, N. Urban, M. Birringer, M. Ristow, Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress, Cell metabolism 6 (2007) 280-293. ACCEPTED MANUSCRIPT [78] A. Sanz, R. Pamplona, G. Barja, Is the mitochondrial free radical theory of aging intact?, Antioxidants & redox signaling 8 (2006) 582-599. [79] A.J. Lambert, M.D. Brand, Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I), The Journal of biological chemistry 279 (2004) 39414-39420. [80] T.B. Sherer, J.R. Richardson, C.M. Testa, B.B. Seo, A.V. Panov, T. Yagi, A. Matsuno-Yagi, G.W. Miller, J.T. Greenamyre, Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of 49
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Page 83 and 84: ACCEPTED MANUSCRIPT Ferrante, N.W.
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