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201-205. ACCEPTED MANUSCRIPT [171] K.F. Winklhofer, The parkin protein as a therapeutic target in Parkinson's disease, Expert Opin Ther Targets 11 (2007) 1543-1552. [172] E.K. Tan, K.Y. Puong, D.K. Chan, K. Yew, S. Fook-Chong, H. Shen, P.W. Ng, J. Woo, Y. Yuen, R. Pavanni, M.C. Wong, K. Puvan, Y. Zhao, Impaired transcriptional upregulation of Parkin promoter variant under oxidative stress and proteasomal inhibition: clinical association, Hum Genet 118 (2005) 484- 488. [173] Y. Imai, M. Soda, R. Takahashi, Parkin suppresses unfolded protein stress- induced cell death through its E3 ubiquitin-protein ligase activity, The Journal of biological chemistry 275 (2000) 35661-35664. [174] M.D. Ledesma, C. Galvan, B. Hellias, C. Dotti, P.H. Jensen, Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress, Journal of neurochemistry 83 (2002) 1431-1440. [175] Y. Higashi, M. Asanuma, I. Miyazaki, N. Hattori, Y. Mizuno, N. Ogawa, Parkin attenuates manganese-induced dopaminergic cell death, Journal of neurochemistry 89 (2004) 1490-1497. ACCEPTED MANUSCRIPT [176] K.F. Winklhofer, J. Tatzelt, C. Haass, The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases, The EMBO journal 27 (2008) 336-349. [177] M.J. LaVoie, G.P. Cortese, B.L. Ostaszewski, M.G. Schlossmacher, The effects of oxidative stress on parkin and other E3 ligases, Journal of neurochemistry 103 (2007) 2354-2368. [178] I.H. Henn, J.M. Gostner, J. Tatzelt, K.F. Winklhofer, Pathogenic mutations inactivate parkin by distinct mechanisms, Journal of neurochemistry 92 (2005) 63
114-122. ACCEPTED MANUSCRIPT [179] J.S. Schlehe, A.K. Lutz, A. Pilsl, K. Lämmermann, K. Grgur, I.H. Henn, J. Tatzelt, K.F. Winklhofer, Aberrant folding of pathogenic parkin mutants: aggregation versus degradation, The Journal of biological chemistry 283 (2008) 13771-13779. [180] K.F. Winklhofer, I.H. Henn, P. Kay-Jackson, U. Heller, J. Tatzelt, Inactivation of parkin by oxidative stress and C-terminal truncations; a protective role of molecular chaperones, The Journal of biological chemistry 278 (2003) 47199- 47208. [181] M.R. Cookson, P.J. Lockhart, C. McLendon, C. O'Farrell, M. Schlossmacher, M.J. Farrer, RING finger 1 mutations in Parkin produce altered localization of the protein, Human molecular genetics 12 (2003) 2957-2965. Epub 2003 Sep 2930. [182] W.J. Gu, O. Corti, F. Araujo, C. Hampe, S. Jacquier, C.B. Lucking, N. Abbas, C. Duyckaerts, T. Rooney, L. Pradier, M. Ruberg, A. Brice, The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates, Neurobiology of disease 14 (2003) 357-364. ACCEPTED MANUSCRIPT [183] E. Kyratzi, M. Pavlaki, D. Kontostavlaki, H.J. Rideout, L. Stefanis, Differential effects of Parkin and its mutants on protein aggregation, the ubiquitin-proteasome system, and neuronal cell death in human neuroblastoma cells, Journal of neurochemistry 102 (2007) 1292-1303. [184] S.R. Sriram, X. Li, H.S. Ko, K.K. Chung, E. Wong, K.L. Lim, V.L. Dawson, T.M. Dawson, Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin, Human molecular genetics 14 (2005) 2571-2586. 64
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