Unusual Causes of Stroke - Hypercoagulable States and their work-up
Unusual Causes of Stroke - Hypercoagulable States and their work-up
Unusual Causes of Stroke - Hypercoagulable States and their work-up
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AAntiphospholipid h h l dA Antibodies b d<br />
• Can be found in 2-12% <strong>of</strong> normal individuals<br />
– Incidence increases with age g<br />
– May be transient (e.g. with infectious mononucleosis)<br />
• Not all are pathogenic<br />
– ACA type A antibodies bind to β2 glycoprotein 1 to<br />
procoagulant lipid surfaces <strong>and</strong> are thought to be<br />
pathogenic<br />
– ACA type B antibodies: do not bind <strong>and</strong> are not<br />
pathogenic p g
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