Unusual Causes of Stroke - Hypercoagulable States and their work-up
Unusual Causes of Stroke - Hypercoagulable States and their work-up
Unusual Causes of Stroke - Hypercoagulable States and their work-up
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Antiphospholipid Antibody<br />
Syndrome<br />
Clinical<br />
• One or more episodes <strong>of</strong><br />
confirmed thrombosis<br />
– Arteries<br />
– Veins<br />
– Small vessels<br />
• Pregnancy morbidity <strong>and</strong><br />
ffetal ll loss<br />
Immunological<br />
• Serum anticardiolipin<br />
antibody <strong>of</strong> high titer<br />
– IgG or IgM isotype in blood<br />
– On 2 or more occasions, occasions at<br />
least 6 weeks apart<br />
• Prolonged<br />
antiphospholipid-<br />
ti h h li id<br />
dependent coagulation<br />
– L<strong>up</strong>us anticoagulant
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