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Unusual Causes of Stroke - Hypercoagulable States and their work-up

Unusual Causes of Stroke - Hypercoagulable States and their work-up

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Serological Diagnosis:<br />

L<strong>up</strong>us Anticoagulant<br />

• Inhibit phospholipid-dependent coagulation<br />

reactions<br />

• Characteristics <strong>of</strong> test<br />

– Prolonged aPTT<br />

– Nt Not corrected tdb by mixing ii with ithnormal lplatelet-poor ltlt<br />

plasma<br />

– Shortening/correction <strong>of</strong> the prolonged coagulation<br />

time by excess phospholipids<br />

– Exclusion <strong>of</strong> other coagulopathies, eg, factor VIII<br />

inhibitor or heparin p

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